RESUMEN

PURPOSE: An evaluation of the importance of gastrin in the colorectal carcinogenesis in patients with familial adenomatous polyposis was conducted. METHODS: Blood samples from 168 family members of 26 families were investigated for circulating gastrin. Blood was drawn from 65 affected patients, 66 clinically unaffected first-degree relatives, and 37 spouses. RESULTS: We did not find any difference in distribution of serum gastrin among these groups. CONCLUSION: Our results seem to exclude gastrin from being relevant in early carcinogenesis in patients with familial adenomatous polyposis.

Asunto(s)

Poliposis Adenomatosa del Colon/sangre , Gastrinas/sangre , Poliposis Adenomatosa del Colon/genética , Poliposis Adenomatosa del Colon/cirugía , Adolescente , Adulto , Factores de Edad , Anciano , Anastomosis Quirúrgica , Biomarcadores/sangre , Niño , Colectomía , Femenino , Humanos , Íleon/cirugía , Masculino , Persona de Mediana Edad , Proctocolectomía Restauradora , Recto/cirugía