RESUMEN
Twenty four patients of classical marasmus and kwashiorkor along with equal number of healthy controls were selected for the study. Their serum amino acid patterns analysis revealed a mean ratio of glutamate to alanine in fasting samples of normal individuals to be 0.33, while it as 9.3 in kwashiorkor and 1.6 in marasmus. This differences in controls, kwashiorkor and marasmus was statistically significant. This observation may explain evolution of marasmus and kwashiorkor in children with similar diets. On the basis of the present observation it is postulated that in kwashiorkor, the conversion of pyruvate to alanine in presence of glutamate, an aminogroup donor does not proceed normally, resulting in accumulation of glutamate and low alanine. Thus the development of marasmus and kwashiorkor may not be related to dietary inadequacy alone but also to the transaminase function. This could be genetic in origin.
Asunto(s)
Aminoácidos/sangre , Kwashiorkor/sangre , Errores Innatos del Metabolismo/complicaciones , Desnutrición Proteico-Calórica/sangre , Estudios de Casos y Controles , Dieta , Humanos , India/epidemiología , Lactante , Estudios Prospectivos , Desnutrición Proteico-Calórica/epidemiología , Desnutrición Proteico-Calórica/etiologíaRESUMEN
The prevalence of skin and internal malignancies was estimated from the general practitioners' notes of 2247 patients with psoriasis and 4494 age- and sex-matched controls. The prevalence of skin cancer in the psoriatics was 155% that of controls, but this was not significant at the 5% level. Subgroup analysis showed an increase in skin cancers in women (P < 0.05). There was no difference in the age of onset of skin cancers between psoriatics and controls and there was no evidence of a cumulative therapeutic risk. There was no difference in the prevalence of non-skin cancers between psoriatics and controls.
Asunto(s)
Psoriasis/epidemiología , Neoplasias Cutáneas/epidemiología , Adulto , Factores de Edad , Inglaterra/epidemiología , Femenino , Humanos , Masculino , Neoplasias/epidemiología , Prevalencia , Psoriasis/complicaciones , Neoplasias Cutáneas/complicacionesRESUMEN
Four hundred and sixty-two patients suffering from primary irritant hand dermatitis were sent postal questionnaires after 1-16 years regarding the outcome of their dermatitis. Two hundred and thirteen patients replied (a compliance rate of 46%). Of the 213 replies 188 were accepted for analysis, of whom only 58 (30.8%) had complete remission of their dermatitis, whilst 130 patients (69.2%) had continuous, or intermittent disease. Of sixty-four patients who changed their occupation only twenty-one (32.8%) had complete remission of their dermatitis as opposed to thirty-seven (29.8%) of 124 who continued their occupation after the diagnosis of primary irritant hand dermatitis was made. It would appear that the outcome of primary irritant hand dermatitis is not favourable, even after 10 years, and change of occupation has no significant effect.
Asunto(s)
Dermatitis por Contacto , Dermatitis Profesional , Dermatosis de la Mano , Femenino , Estudios de Seguimiento , Humanos , Pruebas del Parche , Pronóstico , Remisión EspontáneaRESUMEN
In a short span of 8 weeks, several patients applied for treatment with glaring clinical manifestations having almost similar se4uence of events, namely urticaria with ma followed by herpes simplex. Seven of these form the subject of the present text.