Asunto(s)
Isquemia Miocárdica , Imagen de Perfusión Miocárdica , Amoníaco , Circulación Coronaria , Humanos , Isquemia , Isquemia Miocárdica/diagnóstico por imagen , Imagen de Perfusión Miocárdica/métodos , Radioisótopos de Nitrógeno , Músculos Papilares/diagnóstico por imagen , Tomografía de Emisión de Positrones/métodos , Tomografía Computarizada de EmisiónRESUMEN
CFTR function is required for normal mucociliary clearance (MCC) and cough-assisted clearance (CC). Lumacaftor-ivacaftor is approved for use in people with cystic fibrosis (CF) carrying two copies of F508del-CFTR. In this observational study performed at four study sites, we characterized the effect of lumacaftor-ivacaftor on mucociliary and cough clearance and related this to other clinical and research endpoints after one month of treatment. Twenty-five adolescents and adults were enrolled. No effect on whole lung MCC was observed, but CC was significantly increased. Sweat chloride improved by 18 mEq/L in this group, indicating a modest restoration of CFTR activity, but no demonstrable change in FEV1 or lung clearance index was observed. We speculate that the modest effect of lumacaftor-ivacaftor on CFTR function was insufficient to yield an improvement in MCC.
Asunto(s)
Aminofenoles/uso terapéutico , Aminopiridinas/uso terapéutico , Benzodioxoles/uso terapéutico , Fibrosis Quística/tratamiento farmacológico , Depuración Mucociliar/efectos de los fármacos , Quinolonas/uso terapéutico , Adolescente , Adulto , Niño , Agonistas de los Canales de Cloruro/uso terapéutico , Estudios de Cohortes , Regulador de Conductancia de Transmembrana de Fibrosis Quística/uso terapéutico , Combinación de Medicamentos , Femenino , Humanos , Estudios Longitudinales , Masculino , Persona de Mediana Edad , Estudios Prospectivos , Adulto JovenRESUMEN
18F-FDG uptake in enlarged lymph nodes is always suspicious, especially in cancer patients. We report a case of hypermetabolic internal mammary lymphadenopathy in a breast cancer patient who was previously treated with bilateral mastectomy and implants. The abnormal nodal uptake turned out to be due to foreign body-induced inflammation, as confirmed histopathologically. Vigilant PET interpretation is required in breast cancer patients who have evidence of breast implant rupture.
Asunto(s)
Implantes de Mama , Neoplasias de la Mama/terapia , Fluorodesoxiglucosa F18 , Granuloma/diagnóstico por imagen , Tomografía Computarizada por Tomografía de Emisión de Positrones , Falla de Prótesis , Siliconas/efectos adversos , Neoplasias de la Mama/complicaciones , Granuloma/complicaciones , Granuloma/etiología , Humanos , Persona de Mediana EdadAsunto(s)
3-Yodobencilguanidina , Cintigrafía , Corazón , Riñón , Radiofármacos , Sistema Nervioso SimpáticoRESUMEN
In cases of nonhereditary osteomalacia associated with hypophosphatemia and inadequate response to vitamin D supplementation, one should consider the possibility of tumor-induced osteomalacia, a paraneoplastic syndrome caused by small mesenchymal tumors often found in obscure locations. We present a case of tumor-induced osteomalacia in which (111)In-pentetreotide scintigraphy aided in accurate localization of the culprit brachial plexus tumor and cure after resection.