RESUMEN
A comparative analysis of the impact of cell therapy (allogenic fetal liver cells, stem cells of autologic bone marrow) on lipid homeostasis, microcirculatory disturbances and structural changes in some organs was made using the atherosclerosis model in guinea-pigs. A positive effect of cell therapy on these parameters was established. The effect was stronger and prolonged after transplantation of stem cells. Atherogenic diet weakens the effect of cell therapy. Thus, cell therapy is more effective in restriction of atherogenic risk factors.
Asunto(s)
Trasplante de Médula Ósea/métodos , Trasplante de Células/métodos , Dislipidemias/terapia , Animales , Aterosclerosis/patología , Aterosclerosis/terapia , Dieta Aterogénica , Dislipidemias/patología , Cobayas , Hígado/embriología , Hígado/patología , Masculino , MicrocirculaciónRESUMEN
We studied the effect of dyslipidemia on lipid metabolism, state of microcirculatory system, and morphological alterations in the aorta and liver of guinea pigs at the early stages of experimental atherogenesis. The important role of microcirculatory disorders in the development of regional pathology and atherosclerosis is confirmed. The proposed alimentary model can be used in the development of novel methods for prevention and treatment of atherosclerosis.
Asunto(s)
Arteriosclerosis/metabolismo , Vasos Sanguíneos/metabolismo , Cobayas/fisiología , Hiperlipidemias/metabolismo , Microcirculación/metabolismo , Animales , Aorta/anatomía & histología , Aorta/metabolismo , Arteriosclerosis/patología , Vasos Sanguíneos/patología , Colesterol en la Dieta , Hiperlipidemias/patología , Metabolismo de los Lípidos , Hígado/anatomía & histología , Hígado/metabolismo , Masculino , Microcirculación/patologíaRESUMEN
We describe the possibility of obtaining cardiomyocyte-like cell cultures from rat, guinea pig, and human bone marrow stromal stem cells. The content of troponin I-positive cells attains 35-45% of the total number of cells in the cultures and persists at this level for up to 4 months under differentiation conditions. Spontaneous contractions of cardiomyocyte-like cells were observed after the formation of cell monolayer under differentiation conditions.