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Clin Transl Oncol ; 10(10): 604-17, 2008 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-18940741

RESUMEN

Worldwide, cervical and uterine cancers are the most deadly cancers in women, with high prevalences, especially in developing countries. The Human Protein Atlas (HPA) portal was explored for proteins expressed in a tissue- or cervix and uterine cancer-specific manner. The group of proteins differentially expressed and with enhanced expression in the glandular and surface epithelial (squamous) cells retrieved from HPA were further explored using the Protein Information and Knowledge Extractor (PIKE) portal to compile biological information that is found in different databases, and repositories on the Internet. Thus, the lists of candidate proteins found in HPA, and PIKE portals may be used as a starting point for the discovery and validation of biomarkers for cervix and uterine cancer employing proteomics approaches as described in the present article.


Asunto(s)
Biomarcadores de Tumor/análisis , Biología Computacional , Neoplasias del Cuello Uterino/metabolismo , Biomarcadores de Tumor/metabolismo , Bases de Datos de Proteínas , Neoplasias Endometriales/metabolismo , Femenino , Humanos , Modelos Biológicos , Proteómica/métodos , Programas Informáticos , Neoplasias del Cuello Uterino/diagnóstico
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