RESUMEN
Sixteen patients with angina refractory to medical therapy who were not considered suitable for standard revascularization underwent transmyocardial revascularization with holmium laser. The average age of the patients was 63.2 +/- 10.5 years. All of them had angina class 3 or 4, and 9 (56%) had previously undergone an aortocoronary bypass grafting. Four patients died during the 6-month follow-up period (25%). Among the survivors, anginal class decreased to class 2 or 1 at the 6th month (p = 0.002). Ejection fraction did not change. The ischemic burden by Holter decreased from 85.3 +/- 656 to 5.5 +/- 9.7 min (p = 0.046). Myocardial perfusion with 201Tl single photon emission computed tomography (SPECT) images at rest and after dipyridamole showed a significant improvement among the ischemic treated segments (p = 0.015). Baseline ejection fraction was somehow lower in nonresponsive than in responsive patients (33 +/- 13 vs. 49 +/- 10, p = 0.052). We conclude that transmyocardial laser revascularization with holmium laser is effective in treatment in ischemic patients not amenable to surgery or percutaneous procedures, as previously reported with CO2 laser. Further investigation is needed to determine which clinical profiles identify the patients for whom this therapy is suitable.
Asunto(s)
Angina Inestable/cirugía , Terapia por Láser , Revascularización Miocárdica/métodos , Anciano , Anciano de 80 o más Años , Angina Inestable/diagnóstico , Angina Inestable/fisiopatología , Gasto Cardíaco , Puente de Arteria Coronaria , Ecocardiografía , Electrocardiografía Ambulatoria , Femenino , Estudios de Seguimiento , Humanos , Masculino , Persona de Mediana Edad , Revascularización Miocárdica/mortalidad , Estudios Retrospectivos , Tasa de Supervivencia , Tomografía Computarizada de Emisión de Fotón Único , Resultado del TratamientoRESUMEN
We have analyzed 44 consecutive patients with significant ST-segment depression during the exercise stress test, with the aim of testing the ability of localizing the coronary stenoses. There was a significant correlation only between maximal ST-segment depression in V1-V4 and stenosis in the left anterior descending artery (r = 0.402, p = 0.0067), but the accuracy of the presence of ischemic ST depression in anterior leads to detect disease of the left anterior descending artery was 59% (26 correct, 18 wrong). The low lateral leads (V5 and V6) were the more accurate to detect coronary disease, as much for the left anterior descending artery as for the right or the circumflex coronary arteries. We conclude that ST segment depressions are of little value to localize the coronary stenoses.