RESUMEN
90 female patients suffering from Candida vaginitis were included in an open, mycologically controlled study, carried out at three gynaecological clinics, to investigate the efficacy and tolerance of one single vaginal tablet containing 500 mg clotrimazole (Canesten 1). In 40% of the patients the infection was considered to be mild and in 60% severe. In order to confirm the diagnosis and to evaluate the therapeutic effect (before application and 1 as well as 4 weeks after therapy), the following criteria were considered: (1) identification of Candida species on direct microscopic examination (wet film) and also by culture on a Nickerson medium, and (2) influence on the clinical symptoms, such as itching, burning, pathological changes of the vaginal mucosa, thrush. The principle criterion was the cultural mycological finding. In 79 patients (88%) the culture was negative 1 week after therapy and in 81 (90%) 4 weeks after therapy; 9 patients (10%) were treatment failures with positive cultural findings at the last control. The clinical symptoms improved parallel to the mycological findings. At the controls they had disappeared in the majority (up to 90%) of the affected patients. The favourable impression achieved at consideration of the cultural findings could be confirmed at the overall assessment by the clinicians: 88% of the patients were cured 1 week after application and 90% 4 weeks after application. By means of different criteria the state of disease did not have any influence on the therapeutic success. The 500-mg clotrimazole vaginal tablet was very well tolerated by all patients.
Asunto(s)
Candidiasis Vulvovaginal/tratamiento farmacológico , Clotrimazol/administración & dosificación , Imidazoles/administración & dosificación , Ensayos Clínicos como Asunto , Clotrimazol/uso terapéutico , Femenino , HumanosRESUMEN
In an evaluation of three different treatment regimens miconazole-coated tampons proved to be effective for the relief of vulvovaginal candidal infection. A mycological and clinical cure rate of about 93% was achieved in patients treated with one tampon twice daily (up to a total of 15 tampons); 61% of patients were mycologically cured with a regimen of one tampon daily for only five days. Reinfection rates were less than 4% with all three regimens. The tampons were well accepted by all the patients.
Asunto(s)
Candidiasis Vulvovaginal/tratamiento farmacológico , Imidazoles/administración & dosificación , Miconazol/administración & dosificación , Tampones Quirúrgicos , Adulto , Esquema de Medicación , Femenino , Humanos , Miconazol/uso terapéuticoRESUMEN
A relationship between maternal diabetes and fetal malformations has been recognized for a long time, but there has been considerable difference of opinion about the size of the risk. Several defects of the pelvis and lower limbs appear to be relatively common in offspring of diabetic mothers. In experimental studies a dose relationship has been shown between some drugs (insulin-Trypan blue) and lower limb malformations. Three patients are discribed with congenital malformations with diabetes or prediabetes during pregnancy. Is the caudal regression syndrome a part of a larger syndrome caused by a disturbance of glucose homeostasis?
Asunto(s)
Glucemia/metabolismo , Anomalías Congénitas/etiología , Embarazo en Diabéticas/sangre , Anomalías Congénitas/epidemiología , Femenino , Humanos , Recién Nacido , EmbarazoAsunto(s)
Anticonceptivos Orales Combinados , Anticonceptivos Orales , Etinilestradiol , Norgestrel , Metabolismo de los Hidratos de Carbono , Anticonceptivos Orales/administración & dosificación , Anticonceptivos Orales Combinados/administración & dosificación , Anticonceptivos Orales Combinados/efectos adversos , Evaluación de Medicamentos , Endometrio/patología , Etinilestradiol/administración & dosificación , Etinilestradiol/efectos adversos , Femenino , Humanos , Lípidos/sangre , Hígado/fisiología , Trastornos de la Menstruación/inducido químicamente , Norgestrel/administración & dosificación , Norgestrel/efectos adversos , Embarazo , Progesterona/sangre , Hemorragia Uterina/inducido químicamenteRESUMEN
In a double-blind trial involving 69 patients, the effect of O-(beta-hydroxyethyl) rutoside (HR)* in the treatment of varicosis of pregnancy has been investigated. The number of patients subjectively improving in the active drug group was significantly greater than in the placebo group; patients receiving HR also showed a small but significant decrease in leg circumference. Throughout the eight-week period of the trial, there were only minimal side-effects and healthy babies were delivered with good Apgar-scores.