RESUMEN
BACKGROUND: Impairments of sound discrimination, speech comprehension in background noise, memory, etc. can be assessed within the diagnosis of an auditory processing and perception disorder (AVWS) in a structured manner using the questionnaire (DGPP-AVWS-FB) provided by the German Society for Phoniatrics and Pedaudiology. The aim is to report on experiences with the use of this questionnaire in a pedaudiology practice. In particular, it was to be determined whether information on the auditory behaviour provided by parents is similar or different to information provided by kindergarten teachers (KGK) or teachers at school (LK). METHODS: During a nine-month period, all parents who presented their children to be examined for a possible AVWS were handed the DGPP-AVWS-FB to be completed by them and by KGK/LK. In order to compare the agreement of the judgements, two questionnaires on attention and concentration or on executive functions (DISYPS II, BRIEF or BRIEF-P) were also given. Data from children with peripheral hearing impairment or cognitive developmental disorder were not used. The correlation coefficient was then calculated for the respective items, scales and indices. RESULTS: Completed questionnaires were available at the end of the study period for a total of 20 primary school children and 7 kindergarten children. In kindergarten children, only KGK but not parents, in school children however, 1x only parents, 16x only LK and in the remaining 3 others both parents and LK suspected an impaired auditory processing. The evaluation of the DGPP-AVWS-FB ultimately reflected this different assessment of the symptoms: with the exception of children in whom both parents and LK suspected an AVWS, the information provided by the parents showed only little agreement with the information provided by the KGK/LK. In comparison, the responses to the other two questionnaires were also different, but the data on attention and hyperactivity in kindergarten children tended to be more similar. DISCUSSION: The data presented could be explained by a different behavior of the children at home or in kindergarten/school. It could also be that the same behavior is evaluated differently. Low correlations are already known for questionnaires on attention deficit/hyperactivity disorder and executive functions.For the clinical routine it is recommended to document the reported symptoms standardized with the DGPP-AVWS-FB and in particular to determine whether an abnormal auditory behavior is noticeable in only one or two or more environments.
Asunto(s)
Trastornos de la Percepción Auditiva , Trastorno por Déficit de Atención con Hiperactividad , Humanos , Ruido , Habla , Encuestas y CuestionariosRESUMEN
INTRODUCTION: Genitopatellar syndrome is characterized by absent/hypoplastic patellae, genital and renal abnormalities, dysmorphic facial features, and mental retardation. Cardiac anomalies, ectodermal dysplasia, and radio-ulnar synostosis have been suggested as additional features. DISCUSSION: We report on additional female patient with sensorineural hearing loss, cleft palate, and hypothyroidism in addition to known anomalies. Findings are discussed based on a literature review of the known patients with the genitopatellar syndrome.
Asunto(s)
Anomalías Múltiples/diagnóstico , Fisura del Paladar/diagnóstico , Pérdida Auditiva Sensorineural/diagnóstico , Anomalías Musculoesqueléticas/diagnóstico , Anomalías Urogenitales/diagnóstico , Anomalías Múltiples/genética , Preescolar , Aberraciones Cromosómicas , Fisura del Paladar/genética , Hipotiroidismo Congénito/diagnóstico , Hipotiroidismo Congénito/genética , Anomalías Craneofaciales/diagnóstico , Anomalías Craneofaciales/genética , Discapacidades del Desarrollo/diagnóstico , Discapacidades del Desarrollo/genética , Femenino , Genes Recesivos , Pérdida Auditiva Sensorineural/genética , Cardiopatías Congénitas/diagnóstico , Cardiopatías Congénitas/genética , Humanos , Anomalías Musculoesqueléticas/genética , Rótula/anomalías , Síndrome , Anomalías Urogenitales/genéticaRESUMEN
One major advantage of acutely dissociated inferior colliculus (IC) neurons in electrophysiological investigations is their complete isolation from the surrounding cellular network. In this way, patch-clamp recordings can be performed under controlled conditions to study membrane properties of IC neurons in more detail. The aim of the present study was to adapt a dissociation method for immature IC neurons to the highly sensitive, fragile and vulnerable mature IC neurons of mammals (mice). The modification of a pronase-based dissociation protocol with respect to concentration, incubation time and handling (trituration) of the cells yielded intact, live IC neurons with a clean cell surface so that they were well suited for further electrophysiological investigations in our study. The largely modified dissociation protocol is described in detail and critically discussed.