RESUMEN

The title diphenol, 1a, was synthesized from p,p'-dihydroxy-alpha-truxillic acid and shown to be active as an oral postcoital antifertility agent in rats: ED100 = 100 (micrograms/kg)/day. The oral uterotropic potency was estimated to be 16% of that of diethylstilbestrol (95% confidence limits of potency 8--35%). The structure of the diphenol, 1a, was confirmed by single-crystal X-ray analysis of the dimethyl ether.

Asunto(s)

Anticonceptivos Sintéticos Poscoito/síntesis química , Anticonceptivos Poscoito/síntesis química , Naftoles/síntesis química , Animales , Antineoplásicos , Fenómenos Químicos , Química , Femenino , Masculino , Naftoles/farmacología , Tamaño de los Órganos/efectos de los fármacos , Ratas , Útero/efectos de los fármacos