RESUMEN
The toxicity investigation technology was elaborated, permitting to individualize the indications for application of the hemodiafiltration method in children. There was proposed the method of the blood serum separation on the compounding fractions with subsequent determination of cytolytical activity (toxicity) of every substance with respect to proper leukocytes.
Asunto(s)
Endotoxemia/terapia , Hemodiafiltración/métodos , Niño , Preescolar , HumanosRESUMEN
21 children who died from meningococcemia were studied. Shock disturbances of the microcirculation and thrombocytic part of hemostasis prevailed within first hours of the disease in the form of adrenal hemorrhages and brain edema as immediate cause of death. With an increase of the disease duration, aggregational thrombocytopenia, generalized microthrombosis, coagulopathy, fibrinolysis activation resulted in massive hemorrhages in a number of organs and tissues and manifested in the syndrome of polyorganic failure. No significant differences were found depending upon treatment.