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5.
Ann Pathol ; 30(5): 378-81, 2010 Oct.
Artículo en Francés | MEDLINE | ID: mdl-21055525

RESUMEN

Yolk sac tumours are rare germinal neoplasms that often arise in ovary and testis. Extragonadal localisations such as mediastinum, retroperitoneum, brain and vagina are uncommon. Primary intraperitoneal tumours are exceedingly rare. We report a case of a 16-year-old girl who underwent laparotomy for an acute abdominal pain and circulatory dysfunction. Abdominal exploration disclosed a large mass involving mesentery of the transverse colon associated to three hepatic nodules and abundant peritoneal bleeding. Segmental hepatic resection was performed and the mesenteric mass was removed. Microscopic examination of the pathologic specimen concluded to a yolk sac tumour. Patient underwent intensive chemotherapy; she's free of disease 2 years after diagnosis. Through this case, clinicopathologic features of this rare neoplasm will be discussed.


Asunto(s)
Tumor del Seno Endodérmico/patología , Neoplasias Peritoneales/patología , Adolescente , Femenino , Humanos
6.
Ann Pathol ; 30(5): 394-7, 2010 Oct.
Artículo en Francés | MEDLINE | ID: mdl-21055529

RESUMEN

Malignant germ cell tumors of the ovary are rare representing 3% of all ovarian neoplasms. Hence, they are the most common ovarian malignancy in girls and young women and account for approximately two-thirds of the ovarian cancers that occur in the first two decades of life. Germ cell tumors constitute a heterogeneous group of tumors and are often mixed associating at least two different tumoral components. Exceptionally, sarcomatous areas can be found. We present a case of a 15-year old girl admitted for a voluminous left ovarian mass revealed by pelvic pain. Pathological examination of the dissected material revealed the tumor to be a mixed germ cell tumor (immature teratoma and yolk sac tumor) with rhabdomyosarcomatous component of embryonal type. Clinico-pathological characteristics of such ovarian tumors will be discussed with emphasis on diagnostic difficulties.


Asunto(s)
Neoplasias de Células Germinales y Embrionarias/patología , Neoplasias Ováricas/patología , Femenino , Humanos , Rabdomiosarcoma/patología
7.
Ann Pathol ; 30(4): 321-4, 2010 Aug.
Artículo en Francés | MEDLINE | ID: mdl-20837246

RESUMEN

Primary mantle cell lymphoma of the digestive tract is uncommon; it rarely involves the stomach and generally manifests as a lymphomatous polyposis. Isolated gastric localization is exceedingly rare. We present a case of a 57-year-old man who presented with a six-month history of atypical epigastric pain. Endoscopy revealed a large ulceration of the gastric mucosa. Histological examination of the biopsied specimens concluded to a marginal zone B-cell lymphoma (MALT-type) of low-grade. Patient underwent two courses of anti-Helicobacter pylori therapy followed by chemotherapy, without endoscopic amelioration. Histological control showed the persistence of a nodular lymphomatous proliferation that respects glands. It was made of monotonous small cells reactive with CD5 and cyclin D1. The diagnosis of gastric mantle cell lymphoma was made. No other digestive or nodal localization was found. Patient underwent intensive chemotherapy anti-CD20; he was free of disease three years after diagnosis. Primary mantle cell lymphoma of the stomach is an uncommon neoplasm. Diagnosis is often difficult and requires the use of CD5 to exclude a MALT-cell lymphoma, which is much more frequent in this location.


Asunto(s)
Antineoplásicos/uso terapéutico , Linfoma de Células B de la Zona Marginal/patología , Linfoma de Células del Manto/patología , Neoplasias Gástricas/patología , Antígenos CD20/análisis , Antígenos CD5/análisis , Ciclo Celular , Estudios de Seguimiento , Humanos , Linfoma de Células B de la Zona Marginal/tratamiento farmacológico , Linfoma de Células del Manto/tratamiento farmacológico , Masculino , Persona de Mediana Edad , Neoplasias Gástricas/tratamiento farmacológico
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