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[Lipid peroxidation and ATPase activity in synaptosomal and mitochondrial fractions of the brain in hypoxia]. / Perekisnoe okislenie lipidov i aktivnost' ATFaz v sinaptosomal'nykh i mitokhondrial'nykh fraktsiiakh mozga pri gipoksii.

Dzhafarov, A I; Magomedov, N M; Babaev, Kh F; Akhmedova, G Sh; Bekhbudova, Z A.

Vopr Med Khim ; 35(4): 51-6, 1989.

Artículo en Ruso | MEDLINE | ID: mdl-2554591

RESUMEN

Acute hypoxia was accompanied by intensification of lipid peroxidation in synaptosomal and mitochondrial rat brain fractions as well as by inhibition of Na+, K+- and Mg2+-ATPases. Preadministration of antioxidants vitamin E and ionol into animals prevented distinctly the increase in lipid peroxidation rate, while the ATPases activity was unaltered. Inhibition of the ATPases may be considered as a result of impairing effect of the lipid peroxidation products, which appears to be of importance for structure-functional deteriorations of the nervous system in hypoxia.

Asunto(s)

Adenosina Trifosfatasas/metabolismo , Encéfalo/enzimología , Hipoxia/metabolismo , Peroxidación de Lípido , Mitocondrias/enzimología , Sinaptosomas/enzimología , Animales , ATPasa de Ca(2+) y Mg(2+)/metabolismo , Hipoxia/enzimología , Ratas , Ratas Endogámicas , ATPasa Intercambiadora de Sodio-Potasio/metabolismo

RESUMEN

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