RESUMEN

We describe the isolation of (-)-lomaiviticins C-E (6-8), elucidation of the complete absolute and relative stereochemistry of (-)-lomaiviticin A (1), the synthetic conversion of (-)-lomaiviticin C (6) to (-)-lomaiviticin A (1), and the first evidence that the dimeric diazofluorene of (-)-lomaiviticin A (1) plays a defining and critical role in antiproliferative activity.

Asunto(s)

Fluorenos/aislamiento & purificación , Fluorenos/química , Espectroscopía de Resonancia Magnética , Estructura Molecular , Relación Estructura-Actividad