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The content of seven main biometals: sodium, potassium, calcium, magnesium, zinc, copper, iron was studied in the blood serum of patients with alcoholic affection of the liver verified clinically and morphologically. In contrast to literature data, it has been established that the levels of the main elements in the blood serum of patients with alcoholic affections of the liver may be normal, and concentrations of zinc, copper and iron are even elevated. The initial body mass of patients significantly influences the mineral spectrum of the blood serum: the levels of zinc and copper in patients with excessive body mass and obesity were significantly higher than in those with normal body mass. The content of the main elements in the blood serum was not changed in relation to the degree of the liver affection and alimentary therapy.

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Basic directions in obesity control are considered in relation to age, complications and form of the disease. Therapeutic potential of diets, surgery and chemotherapy are analyzed. It is hold, that a combined approach to obesity management may be most beneficial, that obese subjects should be placed under outpatient observation.

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Screening examination of 12,191 students in their first year of study at medical faculties and technical institutes in Moscow, Kharkov, Alma-Ata and Tashkent showed the following prevalence of major risk factors of ischaemic heart disease among males and females: arterial hypertension: 4.6-17%; 1.2-6.5%; smoking: 20.2-41.0%; 0-3.5%; overweight 6.2-16.9%; 8.1-18.3%; low physical activity: 35.0-67.4%; 40.7-86.4%. Active intervention aimed at preventing the mentioned risk factors, carried out in Kharkov (2 years) and in Alma-Ata (1 year) led to a decrease in the prevalence of arterial hypertension and smoking, and to an increase in the degree of the student's physical activity, but did not have a demonstrable effect on the development of overweight.

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Protein metabolism was studied in patients with alimentary obesity. It was found that the reduction of excessive body weight under the action of a complex of measures, including dietetics, exercise therapy and physiotherapy, induced positive shifts in the amino acid spectrum of blood. The blood serum creatinine content and urinary excretion of creatinine and creatine remained unchanged. The nitrogenous balance was maintained even in cases of highly restricted diets.

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Asymptomatic hyperuricemia was recognized in 344 patients with obesity. The use of low-calorie diets led to a reduction in the body weight and made purine metabolism more normal. The correcting effect was most remarkable with the use of low-caloric diets with a low purine content. Inasmuch hyperuricemia of long standing plays an important role in the development of podarga, atherosclerosis, it is recommended that obese patients should be treated with the diets with a low content of food purines.

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The authors summarize the data on many years of study of the effect of the diet with an extremely reduced caloricity (2500 kj or 600 kcal) on the clinical, biochemical and morphometry parameters in patients with different degrees of obesity. A total of 148 patients aged 17 to 52 years were placed under observation. The investigations confirm that the nutrition regimens under consideration are well tolerated by patients, favouring the improvement of lipid metabolism, reduction in the level of glycemia and insulinemia and making cortisol and glucagon secretion return to normal. At the same time the low protein quota in the diet, noticeable disorders in protein metabolism (negative nitrogenous balance, an increase in the uric acid content in blood serum) attest to the necessity of being cautious in prescribing the diets with an extremely reduced caloricity. It is not advisable that the diets under consideration should be employed under inpatient conditions for more than 1-1.5 month.

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The increasing prevalence of overweight and obesity, the classification of the population whose age is the most favourable for working activities as patients, considerable prevalence of the disease among children and young people, the disease progress and severe complications make obesity one of the most important problems today. The development of obesity and complications is mainly caused by energy imbalance which gets aggravated in subjects manifesting lipid metabolism pathology. Disorders in the character and rhythm of nutrition are most remarkable in cases of obesity complicated by cardiovascular pathology, diseases of the hepatobiliary system, diabetes mellitus, and so forth. Taking into consideration the significance of the problem of obesity the Institute of Nutrition, Academy of Medical Sciences of the USSR, developed a program of measures whose realization will favour the solution of the Food Program.

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The immune status was examined in 126 patients with malabsorption. Of these, 100 subjects suffered from chronic enteritis of varying severity. Twenty-six patients developed malabsorption after extensive resection of the small intestine. Lymphocyte proliferation and migration of peripheral blood leukocytes exposed to PHA served as immunologic criteria. The secondary immunodeficient status ascertained by the authors correlated with the disease severity and stage. The diets differing in the protein quota (100, 130, 160 g) were applied as the basic therapeutic factor. The best effect was attained with the diet containing 130 g protein which makes it possible to use it for immunocorrection in secondary immunodeficient states of varying etiology.

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