Asunto(s)
Serodiagnóstico del SIDA , Donantes de Sangre , Transfusión Sanguínea/normas , Ensayo de Inmunoadsorción Enzimática/métodos , Infecciones por VIH/prevención & control , Tamizaje Masivo , Infecciones por VIH/sangre , Infecciones por VIH/epidemiología , Humanos , Italia/epidemiología , Estudios Multicéntricos como Asunto , Prevalencia , Garantía de la Calidad de Atención de SaludRESUMEN
Hundred-eighty patients, aged between 18 and 58 years, participated in a multicenter study, in order to assay the efficacy and tolerability of nimesulide in gynaecological inflammatory diseases. Thirty patients were affected by adnexitis, 41 patients by cervicitis, 6 by endometritis, 13 by myometritis and 90 patients presented more pathologies associated. Al the patients were treated with nimesulide 100 mg granular (sachets) bid for a mean period of 19 days. Treatment with nimesulide produced good results in all pathologies, significantly reducing the intensity of symptomatology. The tolerability of the drug was always good.
Asunto(s)
Antiinflamatorios no Esteroideos/uso terapéutico , Enfermedades de los Genitales Femeninos/tratamiento farmacológico , Sulfonamidas/uso terapéutico , Adulto , Ensayos Clínicos como Asunto , Evaluación de Medicamentos , Endometritis/tratamiento farmacológico , Femenino , Humanos , Persona de Mediana Edad , Estudios Multicéntricos como Asunto , Miometrio/efectos de los fármacos , Miometrio/fisiopatología , Enfermedad Inflamatoria Pélvica/tratamiento farmacológico , Sicilia , Cervicitis Uterina/tratamiento farmacológicoRESUMEN
The antihepatotoxic properties of uridine-diphosphoglucose (UDPG, Toxepasi) have been evaluated in a well-established model of liver damage, the liver fluke infection (experimental fascioliasis in the rat), which causes a dramatic loss of the microsomal drug-metabolizing monooxygenase (MFO) and glucuronosyltransferase (GT) enzyme systems as a consequence of peroxidative damage to microsomal membrane lipids. Administration of 100 mg/kg UDPG i.p. to the infested rat for the entire course of the infection (40 days) positively affects the parameters reflecting the integrity of the liver cell (serum glutamate-pyruvate, GPT and glutamate-oxaloacetate, GOT, transaminases) and the detoxifying capacity of the liver (cytochrome P-450, cytochrome b5, cytochrome P-450-dependent p-nitroanisole O-demethylase and aniline hydroxylase activities, and the p-nitrophenol glucuronidation) and greatly reduces the lipid peroxidative phenomen in membranes from whole liver (tissue malonic dialdehyde content) and in membranes of the microsomal fraction (conjugated diene absorption). As a consequence of this, the total lipid and phospholipid contents of the liver are restored, there is minimal loss of latency of GT enzyme(s), cytochrome P-450 conversion to cytochrome P-420 is fairly negligible and total liver glutathione content is also restored. Therefore, UDPG restores liver function by protecting the endoplasmic reticulum membranes from the oxidative stress resulting from activation of the CN-insensitive respiratory burst of the phagocytic cells consequent to Fasciola hepatica invasion, migration and growth. It is very likely that UDPG acts as an effective antilipoperoxidative agent through both direct (as demonstrated by our in vitro experiments) and indirect mechanisms (stimulation of the glycolytic pathway, and hence of the reducing equivalents----glutathione----vitamin E supply).(ABSTRACT TRUNCATED AT 250 WORDS)
Asunto(s)
Fascioliasis/tratamiento farmacológico , Uridina Difosfato Glucosa/uso terapéutico , Azúcares de Uridina Difosfato/uso terapéutico , Animales , Sistema Enzimático del Citocromo P-450/metabolismo , Fasciola hepatica , Fascioliasis/parasitología , Heces/parasitología , Glucuronosiltransferasa/metabolismo , Glutatión/metabolismo , Técnicas In Vitro , Peroxidación de Lípido/efectos de los fármacos , Pruebas de Función Hepática , Masculino , Microsomas Hepáticos/efectos de los fármacos , Microsomas Hepáticos/enzimología , Oxigenasas de Función Mixta/metabolismo , Ratas , Ratas EndogámicasRESUMEN
Two-hundred and twenty patients, aged between 18 and 71 years, participated in a multicenter study in order to assay the efficacy and tolerability of nimesulide in gynecological inflammatory diseases. Forty and two patients were affected by adnexitis, 37 by cervicitis, 12 by endometritis, 9 by myometritis and 120 patients presented more pathologies associated. All the patients were treated with nimesulide 100 mg granular (sachets) b.i.d. for a mean period of 19.5 days. The treatment with nimesulide produced good results in all pathologies, significantly reducing the intensity of symptomatology. The tolerability of the drug resulted to be good.