RESUMEN
OBJECTIVE: Calcium antagonists are commonly used drugs in the treatment of hypertension in elderly patients. One of the drugs of this group is verapamil. Especially its slow release formula is convenient for use in elderly patients (drug is given once daily). The aim of our study was to evaluate the antihypertensive efficacy of 240 mg slow release verapamil given once daily in elderly hypertensives using ambulatory blood pressure monitoring (ABPM). We also evaluated the safety of this slow release formula using trough to peak ratio. DESIGN AND METHODS: Twenty hypertensives of mean age 67.5 +/- 5.3 were enrolled into the study. Our study was performed using double-blind, placebo-controlled cross-over study design. After a 2-week wash-out period 24-hour ABPM was performed for the first time and then twice: after 2 weeks of placebo or 240 verapamil slow-release and after 2 weeks of verapamil or placebo treatment. The readings prior to and after the treatment were taken using the same procedure. Blood pressure measurements were recorded every 15 minutes between 7.00 and 23.00 and every 30 minutes between 23.00 and 7.00. RESULTS: Verapamil treatment statistically significantly reduced (p < 0.05) mean 24 hour systolic blood pressure from 148.88 +/- 7.56 mmHg to 132.24 +/- 6.13 mmHg and diastolic respectively from 96.68 +/- 6.05 to 83.04 +/- 5.40 mmHg. Heart rate decreased from 77.16 +/- 3.84 BPM to 68.88 +/- 4.41 BPM. Placebo-corrected trough to peak ratio was 70% for systolic blood pressure.
Asunto(s)
Monitoreo Ambulatorio de la Presión Arterial , Bloqueadores de los Canales de Calcio/uso terapéutico , Hipertensión/tratamiento farmacológico , Verapamilo/uso terapéutico , Anciano , Bloqueadores de los Canales de Calcio/sangre , Bloqueadores de los Canales de Calcio/farmacología , Ritmo Circadiano , Preparaciones de Acción Retardada , Método Doble Ciego , Esquema de Medicación , Femenino , Hemodinámica/efectos de los fármacos , Humanos , Hipertensión/diagnóstico , Hipertensión/fisiopatología , Masculino , Persona de Mediana Edad , Verapamilo/sangre , Verapamilo/farmacologíaRESUMEN
Hundred sixty four measurements of the arterial blood pressure were performed in 53 newborns aged between 1 and 9 days. sphygmomanometer-S used for this purpose is a microcomputer which measures arterial blood pressure basing on the amplitude of the registered pulse waves. Obtained results of the systolic and mean blood pressure values were comparable with those reported by other authors whereas diastolic blood pressure values were somewhat lower.
Asunto(s)
Monitores de Presión Sanguínea , Presión Sanguínea/fisiología , Diagnóstico por Computador , Humanos , Recién Nacido , Microcomputadores , Valores de ReferenciaRESUMEN
The distribution of the mucosal PGE2-generating capacity was bioassayed in the duodenum of 17 patients with duodenal ulcer (age range 20-58 years), and in 17 subjects (age range 21-57 years) who did not suffer from this disease. The age of the subjects within both groups was precisely matched in pairs. In contrast to the "young" controls or the "young" patients (under 37) or the "old" patients (over 37) the "old" control group of subjects showed an age-dependent increase in the mucosal PGE2 generation. It is concluded that with increasing age the mucosal PGE2 plays an increasingly important role in the protection against duodenal ulcers.