RESUMEN
BACKGROUND: A 14-year-old female rhesus monkey (Macaca mulatta) of Chinese origin has been suffering from alopecia universalis since childhood. METHODS: Recently, the health status of the animal was recorded comprehensively by detailed clinical examination including hematology and serology supplemented by histological and immunohistochemical investigations of skin biopsies and molecular biological techniques to clarify the causes of the persistent hair loss. RESULTS AND CONCLUSIONS: The hairless gene (hr) nonsense mutation was ruled out by polymerase chain reaction and by sequencing of the corresponding gene. Histological examinations revealed a prominent chronic lymphocytic perifolliculitis and folliculitis affecting anagen stage hair follicles as well as miniaturized hair follicles. Immunohistochemistry using the antibodies CD3, CD20 and CD4 confirmed the diagnosis of a T-cell-mediated autoimmune disease resembling alopecia areata universalis in humans.
Asunto(s)
Alopecia Areata/veterinaria , Enfermedades Autoinmunes/veterinaria , Macaca mulatta , Enfermedades de los Monos/inmunología , Alopecia Areata/genética , Alopecia Areata/inmunología , Animales , Anticuerpos/análisis , Anticuerpos/metabolismo , Antígenos CD/inmunología , Enfermedades Autoinmunes/diagnóstico , Cartilla de ADN/química , Femenino , Folículo Piloso/patología , Enfermedades de los Monos/diagnóstico , Enfermedades de los Monos/genética , Uñas/patología , Reacción en Cadena de la Polimerasa/veterinaria , Piel/inmunología , Piel/patología , Hormonas Tiroideas/sangreRESUMEN
The clinical findings in a 16-year-old dog with mycosis fungoides are described. The definitive diagnosis was based on the characteristic histopathological lesions in the skin and mucosal biopsies. An immunohistological examination using monoclonal antibodies directed against the Thy-1 antigen of canine peripheral T lymphocytes did not give any further evidence of the identity of the infiltrating lymphoid cells.