RESUMEN
Nickel and cobalt are major components of alloys used in orthodontics. The objectives of this cross-sectional study was to determine the prevalence of a nickel hypersensitivity reaction before and after orthodontic treatment with conventional stainless steel brackets and wires. The total sample consisted of 82 patients (55 females, and 27 males) from the Orthodontic Department at the Faculty of Dentistry, Süleyman Demirel University. A patch test and a questionnaire were used to evaluate hypersensitivity to these metals. The statistical analysis was carried out using Fisher's exact X(2) (2 x 2) test. The prevalence of nickel allergy was found to be higher in females than males (14.55% in females, 0% in males), and the prevalence of cobalt allergy was found to be 9.76% (7.27% in females, 14.81% in males). Orthodontic treatment with conventional stainless steel alloys does not appear to have an allergenic effect on the gingival and oral health of the patient. A family history of an allergy to these metals or the use of metallic objects in contact with the skin do not characterize nickel and cobalt hypersensitivity. This suggests orthodontic therapy with conventional stainless steel appliances does not initiate or aggravate a nickel hypersensitivity reaction. There was no association between the before treatment and after treatment to a nickel and cobalt hypersensitivity reaction.
Asunto(s)
Cobalto/efectos adversos , Aleaciones Dentales/efectos adversos , Hipersensibilidad Tardía/inducido químicamente , Níquel/efectos adversos , Aparatos Ortodóncicos/efectos adversos , Adolescente , Adulto , Distribución de Chi-Cuadrado , Niño , Estudios Transversales , Femenino , Encía/efectos de los fármacos , Humanos , Masculino , Anamnesis , Ortodoncia Correctiva/efectos adversos , Pruebas del Parche , Factores Sexuales , Acero Inoxidable/efectos adversos , Encuestas y CuestionariosRESUMEN
Eczematous external otitis, because of its basic allergic nature, tends to be chronic or recurrent. The purpose of our study was to investigate the association between allergic contact dermatitis and chronic eczematous external otitis. Sixty-six patients with eczematous external otitis and 48 healthy volunteers were included in this study. All the patients were tested with an epicutaneous patch test. In the study group, the average recurrent attack rate was 6.1+/-1.5 (between 4-9 times during the last year) in the patch test positive eczematous external otitis patients, and 4.9+/-1.3 (between 4-8 times during the last year) in the patch test negative patients (p = 0.002). The epicutaneous patch test was positive in 19 (28.8%) out of 66 cases with chronic eczematous external otitis, and in 3 (6.3%) out of 48 cases in the control group. The difference between the two groups was statistically significant (p = 0.003). The most common reactions were due to neomycin sulfate and potassium dichromate in this study. These results suggest that, in some cases eczematous external otitis may be considered as a form of delayed type hypersensitivity to allergen stimuli. Patients suffering from eczematous external otitis symptoms should be investigated for allergens.
Asunto(s)
Dermatitis Alérgica por Contacto/epidemiología , Otitis Externa/complicaciones , Adolescente , Adulto , Enfermedad Crónica , Dermatitis Alérgica por Contacto/diagnóstico , Dermatitis Alérgica por Contacto/etiología , Eccema/complicaciones , Femenino , Humanos , Masculino , Persona de Mediana Edad , Pruebas del Parche , Prevalencia , Recurrencia , Turquía/epidemiologíaRESUMEN
BACKGROUND: Due to the high rate of recurrence, seborrheic dermatitis (SD) represents a therapeutic problem. AIM: To evaluate the role of oral itraconazole in the treatment of SD. PATIENTS AND METHODS: Thirty-two patients with SD were enrolled in the study. All topical and oral treatments were stopped. The patients applied 1% hydrocortisone cream twice daily for 1 month. In addition, they took itraconazole, 200 mg/day, during the first week of the first month and then hydrocortisone cream was stopped and itraconazole (200 mg/day) was given on the first 2 days of the following 11 months. The patients were followed for 2 months without medicine. The severity score was measured at the initial evaluation, and at the first, 12th, and 14th months. RESULTS: Twenty-eight patients completed the study. There was a statistically significant decrease in the mean severity score at the first, 12th, and 14th months. On the final evaluation at the 12th month, 19 of the 28 patients showed a complete improvement, and three patients showed a slight improvement. CONCLUSIONS: This study indicates that itraconazole plays an important role in the treatment of SD.
Asunto(s)
Antifúngicos/uso terapéutico , Dermatitis Seborreica/tratamiento farmacológico , Itraconazol/uso terapéutico , Adolescente , Adulto , Femenino , Humanos , Masculino , Persona de Mediana EdadRESUMEN
Behçet's disease (BD) is an inflammatory multisystem disorder characterized by recurrent oral and genital aphthous ulcers, arthritis, uveitis, and thrombophlebitis; it can involve several organs. However, recurrent aphthous stomatitis (RAS) can be seen without a confirmed diagnosis of BD. Moreover, there is no way of predicting whether a patient with RAS will develop BD. Nitric oxide (NO) is a free radical synthesized from L-arginine by one of the family of nitric oxide synthase (NOS) enzymes. Increased production of NO during several inflammatory and infectious processes has been recently postulated. Our aim was to investigate the serum NO levels in patients with active and inactive BD and RAS. Forty-six patients with BD, 30 patients with RAS and 30 healthy controls were enrolled in the study. The patients with BD were separated into two groups: clinically active (n = 24) and inactive (n = 22). A blood sample was collected from all subjects in order to determine their serum NO levels. In patients with active BD, higher serum levels of NO metabolite were found in comparison with patients with inactive BD, in patients with RAS, or healthy controls (p < 0.05). We also found higher serum NO metabolite levels in patients with RAS than in healthy controls (p < 0.05). In patients with inactive BD, statistically significant higher levels of serum NO levels were found in comparison with the control group (p < 0.05). However, we found no statistically significant difference between the patients with inactive BD and RAS, which indicated that inactive BD cannot be distinguished from RAS by serum NO levels. We conclude that serum NO levels may be an important marker for estimating the severity of BD. However, further studies are needed to confirm our findings.
Asunto(s)
Síndrome de Behçet/sangre , Óxido Nítrico/sangre , Estomatitis Aftosa/sangre , Adulto , Síndrome de Behçet/complicaciones , Estudios de Casos y Controles , Femenino , Humanos , Masculino , Persona de Mediana Edad , Valor Predictivo de las Pruebas , Recurrencia , Estomatitis Aftosa/complicacionesRESUMEN
Chronic urticaria is an important diagnostic and therapeutic problem. We aimed to investigate the sero-prevalence of tissue parasites causing toxocariasis and fasciolosis in patients with chronic urticaria. All cases were analyzed for antibodies against Toxocara canis and Fasciola hepatica by modified (homemade) ELISA. The excretory/secretory products of Toxocara and Fasciola were used as antigens (ES-ELISA) in the test. In this study, the highest toxocariasis seropositivity (29.0%) rate and the highest fasciolosis seropositivity (14.5%) rate were found in patients with chronic urticaria. Fasciolosis seropositivity and total seropositivity of toxocariasis and fasciolosis in patients with chronic urticaria was significantly higher than in healthy controls (p<0.05). Toxocariasis seropositivity in patients with chronic urticaria was not significantly higher than that in healthy controls (p>0.05). We suggest that parasitic infections should be considered as an important cause of chronic urticaria. Serological methods should be used to expose the diagnosis of tissue parasites in such cases.
Asunto(s)
Fascioliasis/epidemiología , Toxocariasis/epidemiología , Urticaria/etiología , Adulto , Animales , Anticuerpos Antihelmínticos/análisis , Anticuerpos Antihelmínticos/sangre , Estudios de Casos y Controles , Enfermedad Crónica , Ensayo de Inmunoadsorción Enzimática , Fasciola hepatica/inmunología , Fascioliasis/sangre , Fascioliasis/complicaciones , Femenino , Humanos , Masculino , Estudios Prospectivos , Toxocara canis/inmunología , Toxocariasis/sangre , Toxocariasis/complicaciones , Turquía/epidemiología , Urticaria/parasitologíaRESUMEN
Behçet's disease (BD) is an inflammatory disease of unknown etiology. Although its pathogenesis is not fully understood, recent studies have suggested that immunological abnormalities and neutrophil hyperfunction may be involved in its etiology and pathophysiology. The immune system in BD can be characterized as a divergent cytokine production profile of the mixed Th1/Th2 cell type. In this study, we investigated the levels of interleukin (IL)-4, IL-10, IL-12, IL-13 and interferon-g in the sera of patients with BD, in comparison with recurrent aphthous stomatitis and healthy controls, to determine the Th1/Th2 profile of the disease. The levels of IL-4, IL-10 and IL-13 were found to be high in active BD patients, and IL-12 and interferon-gamma levels were lower in active BD patients than in inactive BD, recurrent aphthous stomatitis, and control patients.
Asunto(s)
Síndrome de Behçet/inmunología , Interferón gamma/sangre , Interleucinas/sangre , Estomatitis Aftosa , Adolescente , Adulto , Anciano , Síndrome de Behçet/sangre , Síndrome de Behçet/complicaciones , Femenino , Humanos , Masculino , Persona de Mediana Edad , Estomatitis Aftosa/sangre , Estomatitis Aftosa/complicaciones , Estomatitis Aftosa/inmunología , Células TH1/inmunología , Células Th2/inmunologíaRESUMEN
We present an 8-year-old girl with pansclerotic morphea of childhood, a rare, severe variant of localized scleroderma. Various systemic agents and PUVA are used in the treatment of this disease. We used UVA therapy in the treatment of this case.
Asunto(s)
Esclerodermia Localizada/terapia , Terapia Ultravioleta , Niño , Femenino , Humanos , Esclerodermia Localizada/patologíaRESUMEN
Mal de Meleda is a rare form of palmoplantar keratoderma, and recently mutations in the ARS (component) B gene have been identified in families with this disease. We identified a recurrent nonsense mutation, R96X, in four families of Turkish descent. In this report, we demonstrate that these families share a common ancestral haplotype at the mal de Meleda locus, suggesting a founder effect.
Asunto(s)
Antígenos Ly/genética , Codón sin Sentido , Efecto Fundador , Queratodermia Palmoplantar/genética , Activador de Plasminógeno de Tipo Uroquinasa/genética , Secuencia de Bases/genética , Femenino , Genes Recesivos , Haplotipos , Humanos , Queratodermia Palmoplantar/patología , Masculino , Datos de Secuencia Molecular , Linaje , Recurrencia , TurquíaRESUMEN
Oxidative stress may be induced by increasing the generation of reactive oxygen species (ROS) and other free radicals. The generation of ROS is known to be associated with a decrease in antioxidant levels. In the present study, the role of oxidative stress was assessed in the pathogenesis of generalized vitiligo. Superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and glutathione (GSH) levels in erythrocytes and serum malondialdehyde (MDA) and nitric oxide (NO) levels were investigated in 24 patients with generalized vitiligo and 20 healthy controls. Our results indicated that significantly increased levels of erythrocyte SOD, serum MDA, and NO were associated with a marked reduction of erythrocyte GSH-Px and GSH activities in patients with generalized vitiligo (p<0.05). Our observations suggest that the presence of an imbalance in the oxidant-antioxidant system might play a role in the pathogenesis of vitiligo. Our results further support the concept that free radical-mediated damage may be the initial pathogenic event in melanocyte degeneration in generalized vitiligo.