1.
Protein Pept Lett
; 17(7): 889-98, 2010 Jul.
Artículo
en Inglés
| MEDLINE
| ID: mdl-20205650
RESUMEN
Bz(NO(2))-Orn(Boc)-OCH(2)CN was synthesized as an amino acid component with effective and successful orthogonal protection for amino acylation of 5'-O-Pivaloyl nucleosides and preparation of substrates for model ribosome reactions. The synthesis was carried out using suitable combinations of the methods of peptide synthesis and modification of amino acids.
Asunto(s)
Adenosina , Modelos Biológicos , Ornitina/química , Acilación , Adenosina/análogos & derivados , Adenosina/síntesis química , Redes y Vías Metabólicas , Ribosomas
2.
Protein Pept Lett
; 16(4): 392-401, 2009.
Artículo
en Inglés
| MEDLINE
| ID: mdl-19356136
RESUMEN
2'/3'-O-[Bz(NO(2))-Orn(Boc)]-5'-O-Piv-Ado (1) and its deoxy analog: 3'-O-[Bz(NO(2))-Orn(Boc)]-5'-O-Piv-2'-dAdo (2) were designed and synthesized as substrates for the model ribosome reaction we used to demonstrate the crucial role of A76 2'-OH of peptidyl-tRNA in the rate acceleration of peptide bond formation during protein biosynthesis.
Asunto(s)
Adenosina/análogos & derivados , Aminoacil-ARN de Transferencia/metabolismo , Ribosomas/metabolismo , Adenosina/síntesis química , Modelos Biológicos , Biosíntesis de Proteínas
3.
Unambiguous evidence for efficient chemical catalysis of adenosine ester aminolysis by its 2'/3'-OH.
J Am Chem Soc
; 129(18): 5790-1, 2007 May 09.
Artículo
en Inglés
| MEDLINE
| ID: mdl-17429968