RESUMEN
Although many authors have reported several beneficial effects ascribed to xylan, such as inhibitory action on mutagenicity activity, antiphlogistic effects, and mitogenic and comitogenic activities, few papers have investigated a systematic study on the technological properties of this polymer. The aim of the present work was to evaluate xylan as a promise raw material for the pharmaceutical industry. The water-insoluble xylan samples were extracted from corn cobs following several steps. The obtained powered sample was analyzed by infrared and RMN spectroscopy, and characterized regarding their particle size, bulk and tap densities, compressibility index, compactability, Hausner ratio, and angle of repose. According to the results, infrared and RMN spectroscopy were shown to be able to evaluate the xylan structural conformation and composition, respectively. In addition, rheological data demonstrated that xylan powder obtained from corn cobs may be characterized as a material with low density and very cohesive flow properties.
Asunto(s)
Portadores de Fármacos , Sistemas de Liberación de Medicamentos , Polímeros , Zea mays/química , Biotecnología/métodos , Espectroscopía de Resonancia Magnética/métodos , Microscopía Electrónica de Rastreo/métodos , Mutágenos , Tamaño de la Partícula , Polvos , Reología/métodos , Espectroscopía Infrarroja por Transformada de Fourier/métodos , Tecnología Farmacéutica/métodos , Xilanos/químicaRESUMEN
A mixture of eight steroids was separated by HPLC on a silica hydride-based stationary phase modified with a moiety of cholesteryl 10-undecanoate. Within the steroid mixture progesterone showed the longest retention time suggesting the strongest interaction with the stationary phase material. To obtain more detailed information upon the effective separation process, interaction studies were performed by high resolution/magic angle spinning (HR/MAS) NMR spectroscopy recorded in the suspended state. (1)H saturation transfer difference (STD) NMR experiments with T(1rho) suppression showed significant hydrophobic binding affinities of progesterone toward the cholesterol column material. These NMR results can be correlated directly to the chromatographic data obtained by HPLC.