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Transplantation ; 100(1): 233-8, 2016 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-26154392

RESUMEN

BACKGROUND: Patients with proximal forearm and arm transplantation have obtained and/or maintained function of the elbow joint and full active range of motion of the extrinsic muscles of the hand, but with diminished protective sensibility and a lack of good function of the intrinsic muscles. These patients have improved function, as measured by the Disabilities of the Arm, Shoulder and Hand questionnaire. METHODS: We report the case of a 52-year-old man who suffered a high-voltage electrical burn requiring amputation of his upper limbs. He underwent bilateral proximal forearm transplantation in Mexico City in May 2012. RESULTS: At 2-year follow-up, immunosuppressive treatment has not led to metabolic, oncologic, or infectious complications. Keloid scars developed at the graft-recipient interface. There have been 4 acute rejections: the fourth was treated with methylprednisolone, rituximab, and immunoglobulin. Chronic rejection has not been detected. The extrinsic muscles of the wrist and digits have good function. Although the intrinsic muscles demonstrated electrical activity 15 months postoperatively, clinically, they are nonuseful. After 2 years, hand function is sufficient to allow the patient to grasp lightweight and medium-sized objects. The patient's Disabilities of the Arm, Shoulder and Hand questionnaire score improved from 50.00 points to 30.83 points, and his Hand Transplantation Score System rating is good, at 69/73 (right/left) of 100. The patient and his family are very satisfied with the functional and aesthetic outcomes. CONCLUSIONS: Upper arm or proximal forearm transplantation is a reconstructive option for patients who have experienced amputation because of trauma.


Asunto(s)
Quemaduras por Electricidad/cirugía , Traumatismos del Antebrazo/cirugía , Antebrazo/cirugía , Trasplante de Órganos/métodos , Enfermedad Aguda , Amputación Quirúrgica , Fenómenos Biomecánicos , Biopsia , Quemaduras por Electricidad/diagnóstico , Quemaduras por Electricidad/fisiopatología , Evaluación de la Discapacidad , Antebrazo/inervación , Traumatismos del Antebrazo/diagnóstico , Traumatismos del Antebrazo/fisiopatología , Rechazo de Injerto/tratamiento farmacológico , Rechazo de Injerto/inmunología , Humanos , Inmunosupresores/administración & dosificación , Masculino , México , Persona de Mediana Edad , Monitorización Inmunológica , Trasplante de Órganos/rehabilitación , Satisfacción del Paciente , Recuperación de la Función , Factores de Tiempo , Resultado del Tratamiento
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