RESUMEN
Twenty-two families, the ethnic origins of which were Caucasian (16) or mixed Caribbean (6), each with two or three members suffering from sarcoidosis, were studied. The frequency of familial sarcoidosis when all races are considered is 2.4 p. 100 but it is higher in people born in the Caribbean. Clinically, this form is no different from non-familial cases but there is a tendency, especially in homozygotic twins, for the dates of revelation of the disease to be very close to each other, and for the clinical and radiological features and the evolution to be the same. A higher frequency of pairs of the same sex with equal numbers of parent-sibling and sibling-sibling pairs were observed. There was no predominance of mother-sibling with respect to father-sibling pairs. The HLA system study was too fragmented to draw any conclusion about the mode of transmission of familial sarcoidosis.
Asunto(s)
Sarcoidosis/genética , Población Negra , Femenino , Francia , Antígenos HLA/análisis , Humanos , Masculino , Estudios Retrospectivos , Sarcoidosis/diagnóstico , Indias Occidentales/etnología , Población BlancaRESUMEN
The analysis of 12 families with 2 or more members suffering from sarcoidosis led a number of findings:--the increased prevalence of sarcoidosis in persons of mixed race from the French Caribbean), which would suggest the intervention of a racial component in the pathogenesis of sarcoidosis;--the rarity of cases where sarcoidosis affects more than 2 members of the same family;--the preponderance within the same family of subjects of identical sex, whether direct collaterals or a parent-child relationship (20 cases out of 26).--the importance of mother-child transmisstion (5 cases) as opposed to father-child transmission (1 case).