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OBJECTIVE: To evaluate the spectral resolution achieved with a cochlear implant in users who were implanted using round window route electrode insertion versus a traditional cochleostomy technique. METHODS: Twenty-six patients were classified into two groups according to the surgical approach: one group (n = 13) underwent cochlear implantation via the round window technique and the other group (n = 13) underwent surgery via cochleostomy. RESULTS: A statistically significant difference was found in spectral ripple discrimination scores between the round window and cochleostomy groups. The round window group performed almost two times better than the cochleostomy group. Differences between Turkish matrix sentence test scores were not statistically significant. CONCLUSION: The spectral ripple discrimination scores of patients who had undergone round window cochlear implant electrode insertion were superior to those of patients whose cochlear implants were inserted using a classical cochleostomy technique.
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Cóclea/cirugía , Implantación Coclear/métodos , Estomía , Percepción del Habla , Adolescente , Adulto , Humanos , Ventana Redonda/cirugía , Adulto JovenRESUMEN
OBJECTIVE: This study aimed to compare the outcomes of ventilation tube insertion and balloon Eustachian tuboplasty as a first line treatment for otitis media with effusion in children. METHOD: This was a retrospective evaluation of 62 children, 30 cases that underwent balloon Eustachian tuboplasty (group 1) and 32 cases that underwent ventilation tube insertion (group 2), from July 2016 to April 2018. RESULTS: The pre-operative air-bone gap of patients who underwent balloon Eustachian tuboplasty was 15-35 dB (mean: 27.6 ± 8.2 dB). The mean pre-operative air-bone gap decreased to 9.6 dB after a mean of 14.4 months (p < 0.05). The air-bone gap decreased from 25.6 dB to 17.6 dB in the ventilation tube group. There was a significant improvement in the air-bone gap values in both groups; however, this decrease was significantly higher in the balloon Eustachian tuboplasty group (p = 0.043). CONCLUSION: Balloon Eustachian tuboplasty may be an effective and safe method for use as a first-line treatment of otitis media with effusion in children.
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OBJECTIVE: This study aimed to evaluate the long-term results of ossiculoplasty using bone cement. METHOD: Forty patients (24 females and 16 males; mean age: 34.1 ± 11.8 years; range, 9-54 years) with chronic otitis media with perforation but without cholesteatoma who had undergone incudostapedial rebridging ossiculoplasty using bone cement were evaluated retrospectively. Pre-operative and post-operative audiograms were evaluated. Bone conduction, air conduction and air-bone gaps were calculated according to international guidelines. RESULTS: There was a mean reduction in pre-operative and post-operative air conduction (12.30 ± 11.98 dB), and this result was significant (p = 0.0001). There was a mean reduction in pre-operative and post-operative bone conduction (4.30 ± 6.69 dB), and this result was significant (p < 0.0001). The pre-operative air-bone gap was 27.65 dB and decreased to 19.65 dB during follow-up (p = 0.0001). No adverse reactions or complications were observed. CONCLUSION: Bone cement is reliable for the repair of incudostapedial-joint defects.
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Pérdida Auditiva Conductiva/cirugía , Reemplazo Osicular/instrumentación , Otitis Media/cirugía , Cirugía del Estribo/instrumentación , Adolescente , Adulto , Audiometría , Cementos para Huesos , Niño , Femenino , Humanos , Masculino , Persona de Mediana Edad , Otitis Media/complicaciones , Procedimientos de Cirugía Plástica/instrumentación , Estudios Retrospectivos , Resultado del Tratamiento , Adulto JovenRESUMEN
OBJECTIVE: Fascin is an actin-bundling protein found in cell membrane protrusions and increases cell motility. The expression of fascin in epithelial neoplasms has been described only recently. No data are available concerning the role of this protein in invasive cholesteatoma. Thus, we investigated the expression of fascin in cholesteatoma tissue and the relationship between fascin expression and intraoperative evaluation of the destruction of the ossicular chain and extent of disease. METHOD: Cholesteatoma specimens of 28 patients and external auditory canal (EAC) skin specimens of the same patients (as the control group) were collected from mastoidectomies. Immunohistochemical technique was used to investigate the fascin expression in all cholesteatoma tissues and EAC skin specimens. Immunohistochemical staining was assessed semiquantitatively based on the thickness of epithelium. SPSS software version 16.0 (SPSS Inc., Chicago, IL, USA) was performed to statistically analyse the relationships between fascin expression and intraoperative evaluation destruction of ossicular chain and extent of the disease. RESULTS: Immunohistochemically, there was no or very low fascin expression observed in normal epithelial cells of EAC skin, while expressed in cholesteatoma tissue. Also, fascin expression in cholesteatoma tissues was significantly correlated with destruction of ossicular chain and extent of the disease. CONCLUSIONS: Fascin expression is usually found in cholesteatoma epithelium and is correlated with destruction of the ossicular chain and extent of disease. Considering all of the correlations between the clinical and histopathological findings, 'fascin immunoexpression scoring' may be used for histological grading of cholesteatoma.
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Proteínas Portadoras/metabolismo , Colesteatoma del Oído Medio/metabolismo , Colesteatoma del Oído Medio/patología , Proteínas de Microfilamentos/metabolismo , Adulto , Anciano , Biomarcadores/metabolismo , Colesteatoma del Oído Medio/cirugía , Osículos del Oído/metabolismo , Osículos del Oído/patología , Femenino , Humanos , Inmunohistoquímica , Masculino , Persona de Mediana Edad , Invasividad NeoplásicaRESUMEN
AIMS: To report the outcomes of the use of intracameral bevacizumab for iris neovascularization occurring after silicone oil (SO) removal in eyes undergoing vitreoretinal surgery (VRS). MATERIAL AND METHODS: This study included 12 eyes that had iris neovascularization after SO removal. The clinical outcomes of 12 eyes after intravitreal bevacizumab injection were reviewed. RESULTS: There were eight men and four women with an average age of 41.58+/-12.68 years. All eyes had VRS for various vitreoretinal diseases. After the mean follow-up period of 9.7+/-5.3 months, SO removal was performed. Then, the patients were followed for more than 2 months and detailed retinal examinations and intraocular pressure (IOP) were normal during this period, but rubeosis iridis (RI) developed. RI was treated with 1 dose of 1.25 mg bevacizumab into the anterior chamber. After a mean follow-up period of 4.8+/-2.2 months, the regression of iris neovacularization was detected and IOP was below 21 mmHg in all eyes. CONCLUSION: Anterior segment neovascularization (ASNV) may develop through various mechanisms in patients with VRS after SO removal, and anterior chamber injection of bevacizumab may lead to regression of ASNV.
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Inhibidores de la Angiogénesis/uso terapéutico , Anticuerpos Monoclonales/uso terapéutico , Iris/irrigación sanguínea , Neovascularización Patológica/tratamiento farmacológico , Aceites de Silicona/uso terapéutico , Cirugía Vitreorretiniana/efectos adversos , Adulto , Anciano , Anticuerpos Monoclonales Humanizados , Bevacizumab , Femenino , Estudios de Seguimiento , Humanos , Inyecciones , Presión Intraocular , Masculino , Persona de Mediana Edad , Neovascularización Patológica/etiología , Vitrectomía/métodos , Adulto JovenRESUMEN
AIM: To describe the use of tissue glue to close scleral and conjunctival wounds, and to compare the clinical outcomes using tissue glue and vicryl suture for closing these areas in conventional 20-gauge (G) vitrectomy. METHODS: Thirty eyes of 30 patients were included in this study. The indications for vitreoretinal surgery were diabetic vitreous haemorrhage with severe vitreoretinal traction in 10 eyes, retinal detachment and proliferative vitreoretinopathy in 14 eyes, and vitreous opacity in 6 eyes. Tissue glue (Tisseel, Baxter AG Industries, Vienna, Austria) was used to attach scleral and conjunctival wounds in 15 eyes and vicryl sutures in 15 eyes. The patients were allotted into two subgroups as tissue glue group (TG) and vicryl suture group (VG). The sclerotomy sites were evaluated with ultrasound biomicroscopy (UBM) postoperatively in TG. Follow-up period was 2 months. The groups were statistically compared for ocular signs and symptoms by Mann-Whitney U-test. RESULTS: No scleral wound leakage and conjunctival reattachment were observed at the end of the surgical procedure and during the follow-up period. No adverse effects were seen in TG. Abnormal fibrous ingrowth was not detected at the sclerotomy sites by means of UBM in TG. Patient comfort was significantly higher in TG than VG (P<0.05). CONCLUSIONS: Tissue glue has no adverse effects on ocular tissue and can be used as a substitute for suture materials, and the use of tissue glue decreases patient symptoms during the postoperative period after 20-G vitrectomy. Tissue glue can enable to perform sutureless surgery in the conventional 20-G vitrectomy.
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Conjuntiva/cirugía , Poliglactina 910 , Esclerótica/cirugía , Técnicas de Sutura , Adhesivos Tisulares/administración & dosificación , Vitrectomía/métodos , Anciano , Conjuntiva/diagnóstico por imagen , Femenino , Humanos , Masculino , Persona de Mediana Edad , Esclerótica/diagnóstico por imagen , UltrasonografíaRESUMEN
PURPOSE: To evaluate the results of extracapsular cataract extraction (ECCE) and phacoemulsification (PHACO) performed in previously vitrectomized eyes. MATERIAL AND METHOD: In this retrospective study, 56 vitrectomized eyes that had ECCE and 60 vitrectomized eyes that had PHACO were included in the study group while 65 eyes that had PHACO in the control group. The evaluated parameters were the incidence of intra-operative and postoperative complications (IPC) and visual outcomes. Chi-squared, independent samples and paired samples tests were used for comparing the results. RESULTS: Deep anterior chamber (AC) was significantly more common in the PHACO group of vitrectomized eyes (PGVE) and observed in eyes that had undergone extensive vitreous removal (p < 0.05). Except for this there were no significant differences in the rate of IPC between the ECCE group and the PGVE (p > 0.05). Some of the intra-operative conditions such as posterior synechiae, primary posterior capsular opacification (PCO) and postoperative complications such as retinal detachment (RD), PCO were significantly more common in vitrectomized eyes than the controls (p < 0.05). There was no significant difference in the visual acuity gain between the ECCE group and the PGVE (p > 0.05). CONCLUSION: Deep AC is more common in eyes with extensive vitreous removal during PHACO than ECCE. Decreasing the bottle height is advised in this case. Except for this, the results of ECCE and PHACO are similar in previously vitrectomized eyes. Posterior synechiaes, primary and postoperative PCO and RD are more common in vitrectomized eyes than the controls.
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Extracción de Catarata/efectos adversos , Vitrectomía , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Extracción de Catarata/métodos , Femenino , Humanos , Masculino , Persona de Mediana Edad , Facoemulsificación/efectos adversos , Facoemulsificación/métodos , Estudios Retrospectivos , Resultado del Tratamiento , Agudeza VisualRESUMEN
PURPOSE: To assess the long-term success rates and complications of heavy silicone oil tamponade (Oxane HD) in the management of complicated retinal detachment with proliferative vitreoretinopathy (PVR). METHODS: Twenty-one eyes of 21 patients with complicated retinal detachment and PVR were included in this study. Vitreoretinal surgery with heavy silicone oil (Oxane HD) tamponade was performed in all patients. Heavy silicone oil was injected by perfluorocarbon liquid-air-silicone oil exchange, and was removed after 3 months. The main outcomes of the surgery including the success and complication rates were evaluated during the mean follow-up period of 11.4+/-0.88 months. Wilcoxon signed ranks test was used for statistical analysis of visual acuity changes. The outcomes of our study were compared with those of the previous studies. RESULTS: All eyes had complicated retinal detachment with PVR Grade C3 or worse. Retinal detachment was rhegmatogenous in 6 eyes, secondary to previous detachment surgery in 11 eyes, secondary to proliferative diabetic retinopathy in 3 eyes, and secondary to perforating eye injury in 1 eye. The overall anatomic success rate was 80.9% at the end of the follow-up period. The overall visual success rate was 42.8%, with no statistically significant difference from baseline (p>0.05). Postoperative complications included severe reproliferation (4 eyes), intraocular pressure rise (3 eyes), anterior dislocation of silicone oil (2 eyes), posterior subcapsular cataract formation (4 eyes), vitreous hemorrhage (1 eye), rubeosis iridis (3 eyes), optic atrophy (1 eye), and ocular pain and photophobia (21 eyes). CONCLUSIONS: According to the results of this study, vitreoretinal surgery with temporary heavy silicone oil tamponade appears to increase the anatomic success rates with minimal complication rate in cases with complicated retinal detachment and PVR.
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Desprendimiento de Retina/cirugía , Aceites de Silicona/administración & dosificación , Vitrectomía/métodos , Vitreorretinopatía Proliferativa/complicaciones , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Niño , Femenino , Estudios de Seguimiento , Humanos , Inyecciones , Masculino , Microscopía Acústica , Persona de Mediana Edad , Estudios Prospectivos , Desprendimiento de Retina/diagnóstico por imagen , Desprendimiento de Retina/etiología , Factores de Tiempo , Resultado del Tratamiento , Agudeza Visual , Vitreorretinopatía Proliferativa/diagnóstico por imagen , Vitreorretinopatía Proliferativa/cirugía , Cuerpo VítreoRESUMEN
OBJECTIVE: The aims of this study were (1) to investigate the pathophysiological characteristics of the middle ear mucoperiosteum against the caustic nature of the gastric content (GC), which consists largely of acid and pepsin components, and (2) to investigate the possible role of gastroesophageal reflux and postoperative vomiting (POV) in the etiology of poststapedectomy granuloma. METHODS: 40 Spraque-Dawley rats of either sex and with a body weight of 200-300 g were used, and divided into different study groups: group 1: GC administration to the middle ear (n = 8); group 2: phosphate-buffered saline administration to the middle ear (n = 8); group 3: GC (pH: 2) administration in the presence of a Teflon piston (TP) (n = 6); group 4: phosphate-buffered saline administration in the presence of a TP (n = 6); group 5: GC administration in the presence of a wired piston (WP) (n = 6); group 6: phosphate- buffered saline administration in the presence of a WP (n = 6). GC was administrated to the middle ear cavities by way of the eustachian tube (ET). In order to overcome the pressure of the ET, a pump mechanism was used. The increased nasopharyngeal pressure caused a passive opening of the ET, and transferred a bolus to the middle ear. The animals were decapitated after 1 week, and the bullae were isolated. The tympanic bullae were serially cut and examined with light microscopy. RESULTS: In the saline controls, there was only a mild amount of polymorphonuclear cell (PMN) infiltration in the mildly thickened subepithelial space, indicating a less pronounced inflammation as compared to the gastric acid group. In the GC group, in addition to focal hemorrhage and severe subepithelial infiltration of PMNs, the middle ear mucosa was dramatically thickened with subepithelial edema and dilated capillaries. In the subepithelial tissue, retention cysts and granulation tissue were present. In the piston groups (TP and WP), there was extensive subepithelial inflammation and edema after GC and saline administrations. Granulation tissue filling the entire bulla around the piston segments was detected. CONCLUSION: The relationship between the administration of GC and middle ear inflammation, and the possible role of POV in the etiology of poststapedectomy granuloma are emphasized with our experimental study. The length of the TP may be considerably important to prevent POV which may lead to gastric reflux to the middle ear.
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Modelos Animales de Enfermedad , Reflujo Gastroesofágico/complicaciones , Granuloma/etiología , Prótesis Osicular , Politetrafluoroetileno , Complicaciones Posoperatorias/etiología , Náusea y Vómito Posoperatorios/complicaciones , Cirugía del Estribo , Presión del Aire , Animales , Oído Medio/patología , Oído Medio/fisiopatología , Trompa Auditiva/patología , Trompa Auditiva/fisiopatología , Femenino , Determinación de la Acidez Gástrica , Reflujo Gastroesofágico/patología , Reflujo Gastroesofágico/fisiopatología , Granuloma/patología , Granuloma/fisiopatología , Granuloma/prevención & control , Humanos , Masculino , Membrana Mucosa/patología , Membrana Mucosa/fisiopatología , Otitis Media/etiología , Otitis Media/patología , Otitis Media/fisiopatología , Otitis Media/prevención & control , Periostio/patología , Periostio/fisiopatología , Complicaciones Posoperatorias/patología , Complicaciones Posoperatorias/fisiopatología , Complicaciones Posoperatorias/prevención & control , Náusea y Vómito Posoperatorios/patología , Náusea y Vómito Posoperatorios/fisiopatología , Ratas , Ratas Sprague-DawleyRESUMEN
PURPOSE: This is a collaborative case-control study from Ophthalmology and Cardiology departments of a tertiary care hospital, designed to explore the relationship between coronary artery disease (CAD) and pseudoexfoliation syndrome (PEX). METHOD: In all, 50 patients with CAD proven by coronary angiography, and 50 controls with normal coronary angiographic findings were compared in terms of PEX, other vascular diseases, and retinal vascular findings. chi2-test and Student's t-test were used for statistical analysis. RESULTS: The number of patients with PEX among CAD (+) patients was substantially larger than controls. In all, 28 of 50 CAD (+) patients and only 12 of 50 CAD (-) patients had PEX. PEX was significantly associated with CAD (P=0.001). When all patients were regrouped according to the presence of PEX, patients with PEX did not differ from patients without PEX in terms of age (P=0.360) and sex (P=0.507), but the prevalence of CAD was higher (P=0.001) and fundoscopic findings of vascular diseases were significantly more prominent (P=0.0001) in PEX (+) patients. DISCUSSION: We demonstrated statistically significant difference in the prevalence of PEX in CAD patients, and also in the prevalence of CAD in PEX (+) individuals. These were striking differences. We should consider the possibility of the presence of PEX in CAD patients; and the predisposition of PEX (+) persons for CAD, which necessitates a fundus examination for findings of systemic vascular diseases.
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Enfermedad de la Arteria Coronaria/complicaciones , Síndrome de Exfoliación/complicaciones , Adulto , Anciano , Estudios de Casos y Controles , Catarata/etiología , Angiografía Coronaria , Enfermedad de la Arteria Coronaria/diagnóstico por imagen , Femenino , Glaucoma de Ángulo Abierto/etiología , Humanos , Masculino , Persona de Mediana EdadRESUMEN
One hundred and forty-seven adult recipients of the Nucleus 24 cochlear implant system, from 13 different European countries, were tested using neural response telemetry to measure the electrically evoked compound action potential (ECAP), according to a standardised postoperative measurement procedure. Recordings were obtained in 96% of these subjects with this standardised procedure. The group results are presented in terms of peak amplitude and latency, slope of the amplitude growth function and ECAP threshold. The effects of aetiological factors and the duration of deafness on the ECAP were also studied. While large intersubject variability and intrasubject variability (across electrodes) were found, results fell within a consistent pattern and a normative range of peak amplitudes and latencies was established. The aetiological factors had little effect on the ECAP characteristics. However, age affected ECAP amplitude and slope of the amplitude growth function significantly; i.e., the amplitude is higher in the lowest age category (15-30 years). Principal component analysis of the ECAP thresholds shows that the thresholds across 5 electrodes can be described by two factors accounting for 92% of the total variance. The two factors represent the overall level of the threshold profiles ('shift') and their slopes across the electrode array ('tilt'). Correlation between these two factors and the same factors describing the T- and C-levels appeared to be moderate, in the range of 0.5-0.6.
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Potenciales de Acción/fisiología , Umbral Auditivo/fisiología , Implantes Cocleares , Adolescente , Adulto , Factores de Edad , Anciano , Electrodos , Femenino , Humanos , Masculino , Persona de Mediana Edad , Factores Sexuales , Telemetría , Factores de TiempoRESUMEN
OBJECTIVE: To determine the importance of supratubal recess in cholesteatoma surgery by presenting the clinical presentation, imaging findings, and surgical treatment methods of 66 patients with cholesteatoma. We propose that the management of supratubal recess allows the opportunity for total removal of the cholesteatoma with the prevention of recurrence. STUDY DESIGN: Retrospective review of surgical cases. SETTING: Tertiary referral center. INTERVENTIONS: Diagnostic and therapeutic procedures were performed. PATIENTS AND METHODS: We present a series of patients with involvement of supratubal recess by reviewing the operative charts of 347 patients surgically treated for aural cholesteatoma between 1990 and 1999. RESULTS: We detected the involvement of supratubal recess in 19% (n = 66) of our operations for aural cholesteatoma removal. CONCLUSION: The intent of this study is to improve the chance for a successful outcome by decreasing the rate of recurrence. The surgical approach to supratubal recess in cholesteatoma operations is emphasized with our series.
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Enfermedades Óseas/cirugía , Colesteatoma/cirugía , Hueso Temporal/cirugía , Adolescente , Adulto , Enfermedades Óseas/diagnóstico , Niño , Preescolar , Colesteatoma/complicaciones , Colesteatoma/diagnóstico , Parálisis Facial/diagnóstico , Parálisis Facial/etiología , Femenino , Estudios de Seguimiento , Humanos , Masculino , Persona de Mediana Edad , Procedimientos Quirúrgicos Otológicos/métodos , Estudios Retrospectivos , Hueso Temporal/diagnóstico por imagen , Tomografía Computarizada por Rayos X , Perforación de la Membrana Timpánica/diagnóstico , Perforación de la Membrana Timpánica/etiologíaRESUMEN
PURPOSE: Two ophthalmic solutions of 0.3% ciprofloxacin eye drops are available in Turkey: Ciloxan and Siprogut. A previous study by the same authors was the first to report vitreous penetration of ciprofloxacin-containing eye drops. The aim of the present study was to compare the levels of drug found in the subretinal fluid by the two products following local administration. METHODS: Forty-three patients undergoing conventional retinal detachment surgery received either Ciloxan (22 patients) or Siprogut (21 patients). Beginning 6 h before surgery, two drops of solution were instilled onto the operative eye every 30 min for the first 3 h and then hourly for the next 3 h. Subretinal fluid samples were collected 30 min after administration of the last dose and were assayed for ciprofloxacin levels using a method involving high-performance liquid chromatography with fluorometric detection. RESULTS: The minimum and maximum subretinal fluid concentrations measured were 0.11 microg/mL and 0.65 microg/mL, respectively, with Ciloxan, and 0.08 microg/mL and 0.62 microg/mL, respectively wth Siprogut. There was no statistical difference between the subretinal fluid ciprofloxacin levels of the two products. The subretinal fluid drug evels attained by both products were below the minimum inhibitory concentrations of common ocular pathogens. CONCLUSIONS: Ciloxan and Siprogut can penetrate subretinal fluid. The ocular bioavailability of ciprofloxacin after local administration is equivalent for both pharmaceutical products.
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Antiinfecciosos/farmacocinética , Ciprofloxacina/farmacocinética , Exudados y Transudados/metabolismo , Retina/metabolismo , Absorción , Administración Tópica , Anciano , Disponibilidad Biológica , Líquidos Corporales/metabolismo , Cromatografía Líquida de Alta Presión , Femenino , Humanos , Masculino , Persona de Mediana Edad , Soluciones Oftálmicas , Desprendimiento de Retina/cirugía , Curvatura de la EscleróticaRESUMEN
The aim of this study was to determine histologic findings in the maxilaarysinus mucosa by scanning electron microscopy (SEM) and transmission electron microscopy (TEM), and ciliary activity within the nasal cavity by measuring the speed of mucociliary transport and after endoscopic sinus surgery (ESS). Thirty patients were enrolled. Thirty-eight antral mucosae of 24 24 patients were investigated according to ultrastructural changes and 6 patients were accepted as controls. At the 12th week, 12 antral nasal mucosae specimens of 8 patients were evaluated. All the specimens were taken from the medial rear wall of the antrum. The specimens were observed under a SEM and TEM. The mucociliary activity was measured within the nasal cavity by a saccharin test in all patients before the operation and after 12 weeks. Twenty people served as controls. In the specimens of the preoperative mucosa, the ciliated epithelium was heavily deciliated, interdigitation of the cell was loosened. In the samples taken 12 weeks after the operation, the ciliated cells were irregularly seen, the number of goblet cells was about the same as in the preoperative group and in the control, the number of the gland openings was higher than in the preoperative group and in the control. Also the interdigitation of the cells was enhanced. The histological and morphological features of the mucosa had improved. The period of the preoperative saccharin test was 12.15 minutes, whereas the period of the postoperative test was 9.08 minutes. The improvement was significant but both results were also significantly longer compared to the controls. These observations suggest that the histological, morphological and mucocilliary activity of the mucosa have not yet improved completely, it takes more than 12 weeks to recover, and the patients should be closely monitored in the postoperative months.
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Endoscopía , Seno Maxilar/fisiología , Depuración Mucociliar/fisiología , Senos Paranasales/cirugía , Cicatrización de Heridas/fisiología , Adolescente , Adulto , Femenino , Humanos , Masculino , Seno Maxilar/patología , Microscopía Electrónica de Rastreo , Persona de Mediana Edad , Membrana Mucosa/patología , Mucosa Nasal/patología , Sinusitis/patología , Sinusitis/cirugíaRESUMEN
AIMS: To investigate the subretinal fluid (SRF) penetration of ciprofloxacin following topical, oral, and combined administration. METHODS: 34 patients undergoing conventional retinal reattachment surgery were randomly assigned to three groups. Twelve patients received topical ciprofloxacin, 11 patients received oral ciprofloxacin, and the other 11 patients received combined drug administration. SRF drug level was measured by using high performance liquid chromatography method. RESULTS: The highest drug concentrations of all tested modes were attained following combined administration and lowest following topical administration (p<0.001). The SRF drug concentration following oral administration was also significantly higher than that of topical administration (p<0.001). Concentrations after oral and combined administration did not differ significantly (p = 0.217). CONCLUSIONS: Topical ciprofloxacin can penetrate SRF. Ocular bioavailability of ciprofloxacin in SRF after oral and combined administration is equivalent.
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Antiinfecciosos/farmacocinética , Humor Acuoso/metabolismo , Ciprofloxacina/farmacocinética , Retina/metabolismo , Adulto , Antiinfecciosos/administración & dosificación , Ciprofloxacina/administración & dosificación , Combinación de Medicamentos , Femenino , Humanos , Masculino , Desprendimiento de Retina/cirugía , Estadísticas no Paramétricas , Cuerpo Vítreo/metabolismoAsunto(s)
Lesiones Oculares/etiología , Arteria Oftálmica/lesiones , Fútbol/lesiones , Hemorragia Vítrea/etiología , Adolescente , Lesiones Oculares/diagnóstico por imagen , Angiografía con Fluoresceína , Humanos , Cristalino/irrigación sanguínea , Cristalino/embriología , Masculino , Arteria Oftálmica/diagnóstico por imagen , Arteria Oftálmica/embriología , Ultrasonografía , Cuerpo Vítreo/irrigación sanguínea , Cuerpo Vítreo/embriología , Hemorragia Vítrea/diagnóstico por imagenRESUMEN
PURPOSE: To assess the outcome of simultaneous phacoemulsification, pars plana vitrectomy, intraocular foreign-body extraction, and intraocular lens (IOL) implantation. SETTING: SSK Ankara Eye Hospital, Department of Vitreoretinal Surgery, Ankara, Turkey. METHODS: Seventeen patients with corneal perforation, intraocular foreign body, vitreous hemorrhage, and lens opacity had simultaneous clear corneal phacoemulsification, pars plana vitrectomy, intraocular foreign-body extraction, and IOL implantation. RESULTS: Postoperative complications included massive retinal fibrosis in 2 patients, retinal detachment in 1, and cilioretinal artery occlusion in 1. At a mean follow-up of 15.2 months, best corrected visual acuity improved in the remaining 13 eyes (76%). The IOL was stable in all cases. CONCLUSION: Combined phacoemulsification with IOL implantation and vitreoretinal surgery was safe in selected cases of penetrating ocular trauma resulting from an intraocular foreign body.
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Lesiones de la Cornea , Cuerpos Extraños en el Ojo/cirugía , Implantación de Lentes Intraoculares , Cristalino/lesiones , Facoemulsificación , Vitrectomía , Cuerpo Vítreo/lesiones , Adolescente , Adulto , Catarata/etiología , Córnea/cirugía , Cuerpos Extraños en el Ojo/complicaciones , Lesiones Oculares Penetrantes/complicaciones , Lesiones Oculares Penetrantes/cirugía , Humanos , Complicaciones Intraoperatorias , Cristalino/cirugía , Masculino , Complicaciones Posoperatorias , Resultado del Tratamiento , Agudeza Visual , Cuerpo Vítreo/cirugía , Hemorragia Vítrea/etiología , Hemorragia Vítrea/cirugíaRESUMEN
BACKGROUND AND OBJECTIVE: To detect the effect of Perfluoroperhydrophenanthrene (vitreon) on intraocular pressure (IOP) changes. PATIENTS AND METHODS: One hundred-five eyes with proliferative vitreoretinopathy undergoing vitrectomy using vitreon as an intraoperative surgical adjunct were randomized to 2 groups. Vitreon was completely removed in 43 eyes (Group A) at the end of operation while it was left intravitreally in 62 eyes (Group B) for 4 weeks. Patients were followed for at least 18 months. RESULTS: During the first postoperative week, 6 eyes (14%) in Group A and 14 eyes (22%) in Group B had IOP of 23 mm Hg or more (P = .393) while no eyes in either group had hypotony. At the last follow-up 2 eyes (5%) in Group A and 6 eyes (10%) in Group B showed chronic hypotony (P = .561). CONCLUSION: Although postoperative chronic hypotony risk increased twofold by vitreon when it was left intravitreally for 4 weeks, this difference was statistically insignificant. Vitreon can be used as a vitreous substitute for 4 weeks in this regard.
Asunto(s)
Fluorocarburos/uso terapéutico , Presión Intraocular/efectos de los fármacos , Vitrectomía/métodos , Vitreorretinopatía Proliferativa/cirugía , Adulto , Anciano , Femenino , Fluorocarburos/efectos adversos , Humanos , Inyecciones , Periodo Intraoperatorio , Masculino , Persona de Mediana Edad , Hipotensión Ocular/inducido químicamente , Hipotensión Ocular/fisiopatología , Pronóstico , Factores de Riesgo , Vitreorretinopatía Proliferativa/fisiopatología , Cuerpo VítreoRESUMEN
AIMS: To assess the subretinal fluid (SRF) levels of ofloxacin following topical, oral or combined administration. METHODS: 31 patients undergoing conventional retinal reattachment surgery were randomly assigned to three groups. Nine patients received topical ofloxacin, 11 patients received oral ofloxacin, and the other 11 patients received combined administration. Collected SRF samples were analysed for drug level by using high performance liquid chromatography. RESULTS: SRF drug levels after oral and combined administration were significantly higher than that after topical administration (p=0.0002 and p=0.0002, respectively) while there was no significant difference between oral and combined administration (p=0.0844). CONCLUSIONS: Ocular bioavailability of ofloxacin in SRF after oral and combined administration is equivalent. The addition of oral ofloxacin to topical therapy increased drug SRF penetration sixfold.