RESUMEN
OBJECTIVE: This study indexed the frequency of psychiatric disorders among hepatitis C virus (HCV)-infected patients. METHOD: HCV-infected patients treated at a university hospital in the northeastern region of Brazil were evaluated in a cross-sectional study using the Mini International Neuropsychiatric Interview. RESULTS: Ninety HCV-infected outpatients were included in the study and 44 (49%) had at least one psychiatric diagnosis. Among the 26 patients (59.1%) with a current psychiatric morbidity, 22 (84.6%) had gone undiagnosed. CONCLUSIONS: HCV-infected patients have a high frequency of unrecognized psychiatric comorbidity.
Asunto(s)
Hepatitis C Crónica/psicología , Trastornos Mentales/epidemiología , Adulto , Brasil/epidemiología , Comorbilidad , Estudios Transversales , Diagnóstico Diferencial , Femenino , Hepatitis C Crónica/virología , Humanos , Entrevista Psicológica , Masculino , Persona de Mediana EdadRESUMEN
Pegylated Interferon-alpha, combined with ribavirin, gives high sustained virological response in patients with hepatitis C virus, an important public health problem and one of the most frequent chronic infectious diseases worldwide. Though it has therapeutic benefits, treatment with IFN-alpha may be complicated by various side effects, especially symptoms of major depression and acute mania. Psychosis is a rare side effect, and its management usually includes discontinuation of IFN-alpha. We report a case of psychotic disorder that occurred during therapy with pegylated Interferon-alpha given associated with ribavirin. After good response to psychiatric treatment, it became possible to finish the anti-viral therapy.
Asunto(s)
Humanos , Masculino , Persona de Mediana Edad , Antivirales/efectos adversos , Interferón-alfa , Polietilenglicoles/efectos adversos , Psicosis Inducidas por Sustancias/diagnóstico , Ribavirina/efectos adversos , Antipsicóticos/uso terapéutico , Quimioterapia Combinada , Hepatitis C Crónica , Psicosis Inducidas por Sustancias/tratamiento farmacológico , Risperidona/uso terapéuticoRESUMEN
Pegylated Interferon-alpha, combined with ribavirin, gives high sustained virological response in patients with hepatitis C virus, an important public health problem and one of the most frequent chronic infectious diseases worldwide. Though it has therapeutic benefits, treatment with IFN-alpha may be complicated by various side effects, especially symptoms of major depression and acute mania. Psychosis is a rare side effect, and its management usually includes discontinuation of IFN-alpha. We report a case of psychotic disorder that occurred during therapy with pegylated Interferon-alpha given associated with ribavirin. After good response to psychiatric treatment, it became possible to finish the anti-viral therapy.