RESUMEN
The frequency of HLA antigens was determined in 82 unrelated patients who had been hospitalized with the most severe form of dengue hemorrhagic fever: shock, dehydration and severe hemorrhages (DHF/DSS). The HLA-A1, HLA-B plank, HLA Cw1 and HLA-A29 antigens showed a significant difference when their values were compared with the normal control group.
Asunto(s)
Dengue/inmunología , Antígenos HLA , Antígenos HLA-A , Antígenos HLA-C , Dengue/genética , Frecuencia de los Genes , Antígenos HLA/genética , Antígeno HLA-A1 , Antígenos HLA-B , Humanos , FenotipoRESUMEN
A child with sickle cell disease presented acute chest syndrome, acute cholestasis and a neurological syndrome. Bilirubin, LDH, alkaline phosphatase, urea and creatinines were markedly increased. Circulating immune complexes were slightly elevated. The patient improved dramatically after a plasma exchange.
Asunto(s)
Anemia de Células Falciformes/complicaciones , Colestasis/terapia , Enfermedad Aguda , Anemia de Células Falciformes/inmunología , Complejo Antígeno-Anticuerpo/análisis , Niño , Colestasis/etiología , Humanos , Masculino , Intercambio PlasmáticoRESUMEN
Clinical and serological studies were carried out on 114 patients admitted to hospital in Havana, Cuba with Dengue Haemorrhagic Fever and Dengue Shock Syndrome (DHF/DSS). Serological confirmation of dengue was obtained in 90% of cases, with 5% of cases primary and 95% secondary. Fever, haemorrhagic manifestations, vomiting and headache were the most frequent signs and symptoms. Among haemorrhagic manifestations, petechiae and vaginal bleeding were reported in a larger number of patients. 21 patients presented shock and, of these, 20 were secondary infections. The disease appeared more frequently in white persons and in women. The aetiopathogenicity of the syndromes is discussed. 95% of the cases could be explained on the basis of the secondary infection hypothesis.