RESUMEN

Lepirudin is indicated for anticoagulation in patients with heparin-induced thrombocytopenia (HIT). We describe 2 cases of HIT and thrombosis in children with heart disease, including one that required extracorporeal membrane oxygenation. Lepirudin, dosed in the recommended adult weight--based fashion, was an effective antithrombotic agent in pediatric patients with HIT.

Asunto(s)

Anticoagulantes/uso terapéutico , Terapia con Hirudina , Hirudinas/análogos & derivados , Proteínas Recombinantes/uso terapéutico , Trombocitopenia/inducido químicamente , Anticoagulantes/administración & dosificación , Cardiomiopatía Dilatada/complicaciones , Niño , Preescolar , Oxigenación por Membrana Extracorpórea , Femenino , Hirudinas/administración & dosificación , Humanos , Proteínas Recombinantes/administración & dosificación