RESUMEN

The prevention of neonatal hyperbilirubinemia by phenobarbital is widely used in many countries. However, dose and period of administration vary according to authors, as the dose-effect relation is not known and since little research in pharmacokinetics of phenobarbital has been done so far. In the present study we compared the effect on serum bilirubin of a single injection of 10 mg/kg body weight and of a prolonged administration of 10 mg/kg/day during 3 days in premature and full-term newborn infants. The single injection had the same effect as the prolonged administration, provided it was given within 12 h after birth.

Asunto(s)

Ictericia Neonatal/prevención & control , Fenobarbital/uso terapéutico , Bilirrubina/sangre , Ensayos Clínicos como Asunto , Evaluación de Medicamentos , Humanos , Recién Nacido , Fenobarbital/administración & dosificación , Factores de Tiempo