RESUMEN
Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an inflammatory neuropathy, which commonly causes peripheral neuropathy. It has rarely been associated with cranial nerve hypertrophy and neuro-ophthalmic manifestations. Proptosis secondary to cranial nerve hypertrophy has been reported in association with CIDP. The authors present a case of a 67-year-old man with CIDP who presented with bilateral proptosis, strabismus, and episodes of globe subluxation. The proptosis was mainly attributed to significant enlargement of the extraocular muscles, in addition to bilateral enlargement of the trigeminal nerves. There has been no published case of CIDP with associated enlargement of extraocular muscles without a history of underlying hyperthyroidism, inflammation, or malignancy. This may represent a new clinical finding in CIDP and adds to the limited literature on the neuro-ophthalmic and orbital associations of CIDP. The proptosis was managed with an uncomplicated bilateral orbital decompression.
Asunto(s)
Exoftalmia , Polirradiculoneuropatía Crónica Inflamatoria Desmielinizante , Anciano , Exoftalmia/diagnóstico , Exoftalmia/etiología , Humanos , Hipertrofia , Masculino , Músculos Oculomotores , Polirradiculoneuropatía Crónica Inflamatoria Desmielinizante/complicaciones , Polirradiculoneuropatía Crónica Inflamatoria Desmielinizante/diagnóstico , CráneoRESUMEN
Multiple myeloma (MM) is the second most prevalent hematologic malignancy after non-Hodgkin lymphoma and is currently considered incurable. Clinical ophthalmic manifestations of MM are rare but at the same time diverse. Ocular surface manifestations of multiple myeloma are uncommon. Conjunctival 'salmon patch' is a typical ocular surface ophthalmological sign with a distinct set of differential diagnoses, including most often ocular adnexal lymphoma. This case report presents a 33-year-old female with a relapse of MM manifesting as a conjunctival 'salmon patch'. The patient initially responded well to medical management including high dose melphalan supported by a third autologous stem cell transplantation (ASCT) and did not require further surgical excision of the ocular lesion. It is suggested that MM should be included in the differential diagnosis of 'salmon patch' conjunctival lesions.
Asunto(s)
Conjuntiva/patología , Neoplasias de la Conjuntiva/diagnóstico , Mieloma Múltiple/diagnóstico , Adulto , Antineoplásicos Alquilantes/uso terapéutico , Terapia Combinada , Neoplasias de la Conjuntiva/terapia , Diagnóstico Diferencial , Femenino , Humanos , Imagen por Resonancia Magnética , Melfalán/uso terapéutico , Mieloma Múltiple/diagnóstico por imagen , Mieloma Múltiple/terapia , Trasplante de Células Madre , Trasplante AutólogoRESUMEN
Wiedemann-Rautenstrauch syndrome (WRS) is a rare neonatal congenital disorder characterized by a progeroid appearance at birth. We report the ocular manifestations of WRS in a 6-year-old boy and compare the findings to previously reported cases. We report for the first time the findings of thin central corneas and lagophthalmos in WRS.