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OBJECTIVE: To investigate the application value of lung ultrasonic on severe high altitude pulmonary edema. METHODS: A prospective, single-blind, case-control study was conducted. Sixty patients with severe high altitude pulmonary edema admitted to Qinghai University Affiliated Hospital from February 2015 to May 2017 were enrolled. The patients were divided into 2 500-3 000 m group, 3 000-3 500 m group and 3 500-4 200 m group according to different altitudes,with 20 patients in each group. The acute physiology and chronic health evaluation II (APACHE II) score was recorded before and 12 hours and 24 hours after treatment. The arterial partial pressure of oxygen (PaO2) was determined by blood gas analysis, and the oxygenation index (PaO2/FiO2) was calculated. Bedside ultrasound scanning was used to determine B line number and pulmonary artery pressure (PAP), and B line score was calculated to reflect lung water content. The correlation between B line score and PaO2/FiO2, PAP and APACHE II scores at each time point was analyzed by Pearson correlation analysis. RESULTS: None of 60 patients died or exited, all of them were enrolled in the final analysis. There was no significant difference in PaO2/FiO2, PAP, APACHE II score or B line score among different altitudes groups (all P > 0.05). Repeated measurement variance analysis showed that the effects of different altitudes on PaO2/FiO2, PAP, APACHE II score and B line score were not statistically significant (F value was 0.312, 0.014, 1.098, 0.236, and P value was 0.340, 0.791, 0.733, and 0.986, respectively). The PaO2/FiO2, PAP, APACHE II score and B line score in all groups were improved obviously from 12 hours after treatment, and the improvements at 24 hours were more than those at 12 hours (all P < 0.05). Repeated measurement variance analysis showed that the effect at different time points on PaO2/FiO2, PAP, APACHE II score and B line score was statistically significant (F value was 1 844.270, 121.690, 1 173.175, 19 426.968, all P < 0.001). The interaction effects of different altitudes and different time points on PaO2/FiO2, PAP, APACHE II score and B line score were not statistically significant (F value was 0.304, 0.404, 1.172, 1.403, and P value was 0.875, 0.805, 0.327, and 0.591, respectively). Pearson correlation analysis showed that there was a significant negative correlation between B line score and PaO2/FiO2 before and after treatment (r value was -0.579, -0.522, and -0.386, all P < 0.01), indicating that the more the B line, the more severe the pulmonary edema, and the worse the oxygenation; with the decrease in B line after treatment, the pulmonary edema was gradually alleviated, and oxygenation was gradually improved. There was a significant positive correlation between B line score and APACHE II score before and 24 hours after treatment (r value was 0.484 and 0.536, both P < 0.01), indicating that the more the B line, the more severe the patient; with the decrease in B line after treatment, the patient's condition improved after treatment. There was only a weak correlation between B line score and PAP at 24 hours after treatment (r = 0.317, P = 0.014), indicating that PAP was not a sensitive indicator in the degree of pulmonary edema in patients. CONCLUSIONS: The more the B line in patients with severe high altitude pulmonary edema, the more severe of the pulmonary edema, and the more severe of the patient. There was no significant correlation between the B line score and PAP. Pulmonary ultrasonography can still be used not only in the plain and low elevation areas, but in the high altitude areas, as a reliable method to evaluate the severity of pulmonary edema.

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Modern vehicles are equipped with a plethora of on-board sensors and large on-board storage, which enables them to gather and store various local-relevant data. However, the wide application of vehicular sensing has its own challenges, among which location-privacy preservation and data query accuracy are two critical problems. In this paper, we propose a novel range query scheme, which helps the data requester to accurately retrieve the sensed data from the distributive on-board storage in vehicular ad hoc networks (VANETs) with location privacy preservation. The proposed scheme exploits structured scalars to denote the locations of data requesters and vehicles, and achieves the privacy-preserving location matching with the homomorphic Paillier cryptosystem technique. Detailed security analysis shows that the proposed range query scheme can successfully preserve the location privacy of the involved data requesters and vehicles, and protect the confidentiality of the sensed data. In addition, performance evaluations are conducted to show the efficiency of the proposed scheme, in terms of computation delay and communication overhead. Specifically, the computation delay and communication overhead are not dependent on the length of the scalar, and they are only proportional to the number of vehicles.

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OBJECTIVE: To compare and analyze Radix Codonopsis from 18 different localities. METHODS: The HPLC was used to detect samples. MATLAB Software and the Computer Aided Similarity Evaluation was used to analyze the fingerprints. Similarity combined with principal component analysis (PCA) were used to compare and analyze Radix Condonopsis in different localities. RESULTS: It was found that processing drugs have effect on the quality of Radix Condonopsis and there are differences in species of Radix Codonopsis. CONCLUSION: This method could be used to compare and analyze the samples of Radix Codonopsis sources.

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