RESUMEN
DNA aneuploidy is common in large renal cortical neoplasms (RCNs), but the incidence in small RCNs is not known. This study was undertaken to investigate whether the traditional 3.0-cm size distinction between small (benign) and large (malignant) tumors might have an objective correlate in the form of abnormal DNA content. Quantitative DNA analysis was performed retrospectively, by image analysis, on 59 RCNs measuring 5.0 cm or less from 30 nephrectomy specimens with solitary tumors and 17 with multiple tumors. DNA indices and the proportion of cells with DNA content greater than that of the G0/G1 population were evaluated with respect to tumor size, stage, and histologic parameters. There was a relationship between the presence of detectable nondiploid stem lines (NDSLs) and tumor size, stage, nuclear grade, and proportion of non-G0/G1 cells, but not histologic pattern. The relationship of NDSLs to tumor size was more apparent in the solitary tumor group, while the relationship of a high proportion of non-G0/G1 cells to tumor size was stronger in the multiple tumor group. Our results show that the incidence of NDSLs increases with tumor size and nuclear grade, and suggest that as RCNs enlarge, the emergence of NDSLs heralds potential biologic aggressiveness. Further, solitary tumors and multiple synchronous tumors may be biologically different in terms of etiologic factors and growth potential.
Asunto(s)
Adenoma/química , Carcinoma/química , ADN de Neoplasias/análisis , Corteza Renal/química , Neoplasias Renales/química , Adenoma/epidemiología , Adenoma/genética , Adulto , Anciano , Anciano de 80 o más Años , Carcinoma/epidemiología , Carcinoma/genética , ADN de Neoplasias/genética , Femenino , Humanos , Procesamiento de Imagen Asistido por Computador , Corteza Renal/patología , Neoplasias Renales/epidemiología , Neoplasias Renales/genética , Masculino , Persona de Mediana Edad , Estudios Retrospectivos , Células Madre/química , Células Madre/patologíaRESUMEN
Renal atheroembolism is a well-recognized cause of renal insufficiency. Two renal allograft recipients with cholesterol atheroemboli in their allograft biopsies are described. In one patient, the origin of the atheroemboli was the recipient aorta while in the second patient the source was the donor. Renal allograft atheroembolism should be considered in elderly recipients or recipients of kidneys from older donors.