RESUMEN
Laryngeal trauma is rare in children due to the anatomical placement and the trauma mechanisms required for injury. Recently the trampoline has become frequent in Danish households leading to more high-energy laryngeal traumas. This case report is about two incidents occurring within a year. The first patient had a laryngeal fracture despite minimum objective findings. The second patient had a compromised airway and needed acute intubation, although she only presented with light hoarseness. We strive to underline the severity of laryngeal trauma in children and briefly discuss the correct handling of these cases.
Asunto(s)
Accidentes Domésticos , Enfermedades de la Laringe , Traumatismos del Cuello , Juego e Implementos de Juego , Niño , Femenino , Humanos , Enfermedades de la Laringe/etiología , Traumatismos del Cuello/etiología , Juego e Implementos de Juego/lesionesRESUMEN
OBJECTIVES: Therapy with mesenchymal stem cells exhibits potential for the development of novel interventions for many diseases and injuries. The use of mesenchymal stem cells in regenerative therapy for vocal fold scarring exhibited promising results to reduce stiffness and enhance the biomechanical properties of injured vocal folds. This study evaluated the biomechanical effects of mesenchymal stem cell therapy for the treatment of vocal fold scarring. DATA SOURCES: PubMed, Embase, the Cochrane Library and Google Scholar were searched. METHODS: Controlled studies that assessed the biomechanical effects of mesenchymal stem cell therapy for the treatment of vocal fold scarring were included. Primary outcomes were viscoelastic properties and mucosal wave amplitude. RESULTS: Seven preclinical animal studies (n = 152 single vocal folds) were eligible for inclusion. Evaluation of viscoelastic parameters revealed a decreased dynamic viscosity (η') and elastic modulus (G'), i.e., decreased resistance and stiffness, in scarred vocal folds treated with mesenchymal stem cells compared to non-treated scarred vocal folds. Mucosal wave amplitude was increased in scarred vocal folds treated with mesenchymal stem cells vs. non-treated scarred vocal folds. CONCLUSION: The results from these studies suggest an increased regenerative effect of therapy with mesenchymal stem cells for scarred vocal folds and are encouraging for further clinical studies.
Asunto(s)
Cicatriz/terapia , Células Madre Mesenquimatosas/citología , Trasplante de Células Madre , Pliegues Vocales/patología , Animales , HumanosRESUMEN
Kaposi's sarcoma is a frequent skin cancer in HIV-positive patients, but is relatively uncommon in HIV-negative and non-immune compromised patients. We present a case of Kaposi's sarcoma of the face and scalp in a HIV-negative male with previous facial basal cell carcinoma.