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1.
Cent Eur Neurosurg ; 72(4): 169-75, 2011 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-22012694

RESUMEN

BACKGROUND: The purpose of this study was to analyse the differences between patients with frontal (FEDH) or parieto-occipital (POEDH) epidural haematomas and evaluate possible statistically significant prognostic factors. MATERIAL AND METHODS: In this retrospective study of a group of 41 patients with a FEDH (17) or POEDH (24 individuals), the authors analysed the influence of gender, age, type of injury, clinical presentation, Glasgow coma scale (GCS) score on admission, radiological findings, and time interval from trauma to surgery on outcomes. A good recovery and moderate disability were considered a "good" or "favourable outcome", whereas severe disability, a vegetative state or death was a "poor outcome". RESULTS: In the POEDH subgroup, a higher GCS score on admission and a younger age were statistically significant prognostic factors for a better outcome (p=0.006, rs=0.702). In the subgroup of patients with FEDHs, the results were not significant. However, patients with FEDHs more frequently had "good outcomes" than members of the POEDH subgroup (88.2 vs. 70.9%). Children (≤ 18 years old) constituted a smaller portion of the POEDH subgroup (12.5%) than those in the FEDH subgroup (41.2%). The evaluation of time intervals between the accident and surgery (≤ 24 h vs. > 24 h) showed no significant influence on outcomes in any of the studied subgroups. However, patients undergoing surgery within 24 h of their injury had a less favourable GCS score on admission than those operated on more than 24 h after their injury. Subacute and chronic clinical courses predominated in patients with a FEDH (10/17 FEDH vs. 11/22 POEDH). Different accompanying intradural lesions occurred in 12 patients of the POEDH subgroup, but only in 2 of the FEDH subgroup (50 vs. 11.8%). However, the presence of such lesions did not significantly deteriorate surgical outcomes in either of the subgroups.


Asunto(s)
Hemorragia Cerebral Traumática/cirugía , Lóbulo Frontal/lesiones , Lóbulo Occipital/lesiones , Lóbulo Parietal/lesiones , Accidentes por Caídas , Accidentes de Tránsito , Adolescente , Adulto , Factores de Edad , Anciano , Niño , Preescolar , Evaluación de la Discapacidad , Duramadre/lesiones , Duramadre/patología , Femenino , Escala de Coma de Glasgow , Escala de Consecuencias de Glasgow , Humanos , Lactante , Recién Nacido , Masculino , Persona de Mediana Edad , Procedimientos Neuroquirúrgicos , Pronóstico , Estudios Retrospectivos , Fracturas Craneales/complicaciones , Tomografía Computarizada por Rayos X , Resultado del Tratamiento , Adulto Joven
2.
Cent Eur Neurosurg ; 71(4): 167-72, 2010 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-20422510

RESUMEN

BACKGROUND: Posttraumatic epidural haematoma (EDH) of the temporal region is the most common site of supratentorial extradural bleeding; other locations are considered atypical. We reviewed 24 patients with EDH located in the posterior cranial fossa (PFEDH) treated at two neurosurgical centres between January 2000 and November 2006. MATERIAL AND METHODS: In the retrospective study we analysed gender and age distribution, type of injury, clinical presentation, Glasgow Coma Scale (GCS) score on admission, radiological images, interval between trauma and surgery, and outcome. RESULTS: 24 patients with PFEDH constituted 11.5% of 209 surgically treated individuals with EDH. The best outcomes were obtained by patients with GCS scores of 15-14 on admission. Patients in the fourth to seventh decade of life had less favourable outcomes than younger ones. More than half of the patients with PFEDH had associated intradural lesions. Only patients with concomitant brain contusion had a more favourable recovery. The 3 worst levels on the Glasgow Outcome Scale (GOS) were observed in patients suffering from subdural or intracerebral haematoma, or both, associated with the PFEDHs. The majority of patients with concurrent lesions and supratentorial extension of the haemorrhage were in the subgroup undergoing craniotomy between 24 and 72 h after injury. Patients treated in this time interval also had the most unfavourable outcomes. A classical lucid interval was observed only in one patient. The mortality rate in the series was 4.2%. CONCLUSION: The most significant factors influencing outcome in our patients were GCS on admission, age, and associated intradural lesions.


Asunto(s)
Fosa Craneal Posterior/patología , Hematoma Epidural Craneal/patología , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Envejecimiento/fisiología , Lesiones Encefálicas/complicaciones , Lesiones Encefálicas/diagnóstico por imagen , Lesiones Encefálicas/cirugía , Tronco Encefálico/patología , Niño , Preescolar , Fosa Craneal Posterior/diagnóstico por imagen , Fosa Craneal Posterior/cirugía , Lateralidad Funcional/fisiología , Escala de Coma de Glasgow , Escala de Consecuencias de Glasgow , Hematoma Epidural Craneal/diagnóstico por imagen , Hematoma Epidural Craneal/cirugía , Humanos , Persona de Mediana Edad , Procedimientos Neuroquirúrgicos , Fracturas Craneales/complicaciones , Tomografía Computarizada por Rayos X , Adulto Joven
3.
Zentralbl Neurochir ; 69(4): 194-9, 2008 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-18666063

RESUMEN

The authors present a case of 44-year-old Caucasian female diagnosed with meningothelial meningioma 40 years after radiotherapy for sporadic unilateral retinoblastoma. The genetic analysis of DNA from the meningioma revealed no oncogenic mutation in the RB1 gene. The analysis of meningioma cells by flow cytometry revealed the following immunophenotype: vimentin++ CD56+ GFAP- EGFR-. Intermediate intensities of Her-2/neu and Pgp expression were detected in a small percentage of tumour cells. Data suggest that the tumour was most likely induced by radiotherapy and did not arise as a second tumour as there was no hereditary predisposition to retinoblastoma.


Asunto(s)
Meningioma/etiología , Meningioma/patología , Radioterapia/efectos adversos , Neoplasias de la Retina/genética , Neoplasias de la Retina/radioterapia , Retinoblastoma/genética , Retinoblastoma/radioterapia , Adulto , Biomarcadores de Tumor , ADN de Neoplasias/genética , Femenino , Citometría de Flujo , Humanos , Inmunohistoquímica , Meningioma/genética , Mutación , Proteínas del Tejido Nervioso/genética , Fenotipo , Tomografía Computarizada por Rayos X
4.
Bratisl Lek Listy ; 108(9): 409-13, 2007.
Artículo en Inglés | MEDLINE | ID: mdl-18225480

RESUMEN

Although precise criteria have not been assessed yet, small haematomas and clinical improvement claim only close observation according to literature. However a question can arise how to advance in patient with vertex epidural haematoma (VEPH) thinner than 10 mm associated with intradural lesions, when his neurological state is improving. The authors present a case of a man who was conservatively treated due to an epidural clot at the vertex associated with intracerebral haematomas, subarachnoid haemorrhage and haemocephalus diagnosed by computed tomography (CT). Despite his neurologically stable condition with slow, but continuous improvement, after few days the patient suddenly died. Authors analyze advantages and disadvantages of conservative vs. surgical treatment of this pathological condition (Fig. 8, Ref. 31). Full Text (Free, PDF) www.bmj.sk.


Asunto(s)
Hematoma Epidural Craneal/terapia , Adulto , Resultado Fatal , Hematoma Epidural Craneal/diagnóstico por imagen , Humanos , Masculino , Tomografía Computarizada por Rayos X
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