RESUMEN
CONTEXT: Serum uric acid (SUA) has been known to be associated with cardiovascular diseases. "Atherogenic index of plasma" (AIP) is considered a very sensitive predictor of future cardiovascular events. OBJECTIVES: This study was conducted to analyse the association of AIP with SUA and various other lipid parameters. METHODS: Parameters were measured on a fully automated analyser using standard reagent kits in a retrospective study involving 248 male Indian subjects between 40 to 59 years of age. RESULTS: AIP correlates: moderately with TC/HDL-C (r = 0.47, p < 0.0001); to a lesser extent but comparably (r = 0.2, p < 0.01) with SUA, LDL-C/HDL-C and TC; negligibly with LDL-C and age. DISCUSSION AND CONCLUSION: As SUA is positively associated with AIP it can be used as a supplementary marker for atherosclerosis/CVD in upper-middle-aged men.
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Aterosclerosis/patología , HDL-Colesterol/sangre , LDL-Colesterol/sangre , Dislipidemias/patología , Ácido Úrico/sangre , Adulto , Biomarcadores/sangre , Humanos , India , Masculino , Persona de Mediana Edad , Juego de Reactivos para Diagnóstico , Estudios Retrospectivos , Factores de RiesgoRESUMEN
BACKGROUND: To find out the incidence of hyperprolactinemia in infertile women and to find its correlation with hypothyroidism. METHODS: One hundred infertile women attending the out patient Department of Obstetrics and Gynaecology formed the subject matter of the study. Hormone levels of prolactin and thyroid stimulating hormone (TSH) were studied in all the subjects. The exclusion criterion was male factor infertility. Amongst the female factors leading to exclusion from the study were tubal factor, congenital abnormality of the urogenital tract, and any organic lesions. RESULTS: Of the one hundred infertile women, sixty (60%) had primary infertility and forty women (40%) had secondary infertility. Galactorrhea was present in 15% of the women. The incidence of hyperprolactinemia i.e. serum prolactin level > 15 ng/mL was 46%. Out of forty six, thirty women had primary infertility and sixteen women had secondary infertility. The mean serum prolactin level in hyperprolactinemic women was 79.40 +56.59 ng/mL (range: 25.0-230.0 ng/mL). The mean serum prolactin level was not significantly different in the primary and secondary infertile group. The incidence of hypothyroidism in hyperprolactinemia was 28.26%. The mean serum TSH level in hypothyroid women with hyperprolactinemia was 32.06 +/- 23.00 (range: 7.92-78.00 microIU/mL). The TSH level was not significantly different in primary and secondary infertile women. CONCLUSIONS: A high incidence of hyperprolactinemia was found in infertile women and a positive correlation was found between hyperprolactinemia and hypothyroidism.
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Hiperprolactinemia/metabolismo , Hipotiroidismo/metabolismo , Infertilidad Femenina/metabolismo , Adulto , Femenino , Humanos , Hiperprolactinemia/complicaciones , Hiperprolactinemia/epidemiología , Hipotiroidismo/complicaciones , Incidencia , Infertilidad Femenina/complicaciones , Estudios ProspectivosRESUMEN
BACKGROUND: Uric acid, the final product of purine catabolism, has been associated with dyslipidemia, most importantly hypertriglyceridemia. But studies on the relation between uric acid and lipid parameters in the Indian population have been minimal. METHODS: Relation between serum uric acid and serum lipids in 121 healthy men, aged 34 to 60 years was studied retrospectively. The subjects were stratified according to age and uric acid levels. All biochemical parameters were measured on automated analysers using reagent kits from standard companies. RESULTS: In men < 45 years in age, those having high serum uric acid levels had a higher serum total cholesterol (p = 0.003), low density lipoprotein cholesterol (p = 0.005), triglycerides (p = 0.02), and very low density lipoprotein cholesterol (p = 0.02) than those having low serum uric acid. Whereas in the > or = 45 year age group when subjects having high serum uric acid were compared to those having low uric acid levels, the only parameters that showed an increase were triglycerides (p = 0.009) and very low density lipoprotein cholesterol (p = 0.008). A statistically significant positive correlation was observed between serum uric acid and serum triglycerides in men of both age groups separately, but between serum uric acid and serum total cholesterol only in the lower age group. CONCLUSIONS: Thus, serum uric acid levels in the normal range might be a good indicator of the level of triglycerides and very low density lipoprotein cholesterol in men encompassing a wide age range but of total cholesterol and low density lipoprotein cholesterol only in men less than 45 years in age.
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LDL-Colesterol/sangre , Ácido Úrico/sangre , Adulto , Factores de Edad , Humanos , Masculino , Persona de Mediana Edad , Valores de Referencia , Triglicéridos/sangreRESUMEN
BACKGROUND: Atherogenic index of plasma, a newly emerging lipid parameter, has been employed only in a few studies in diabetics and not at all in non-diabetics. METHODS: Association between fasting serum glucose and lipid parameters in 321 non-diabetic males aged 30 to 60 years was studied retrospectively. Glucose and lipid parameters were measured on fully automated analyser using standard reagent kits. Body mass index was also ascertained. RESULTS: On comparing the various lipid parameters between normo-glycaemic and pre-diabetic men, a significant increase in TG (p = 0.0328), VLDL-C (p = 0.0328) and AIP (p = 0.0373) was observed only in pre-diabetic men ≥ 45 years. In non-diabetic men ≥ 45 years a slight but statistically positive correlation between glucose and AIP was also seen. CONCLUSIONS: Increased blood glucose in men ≥ 45 years, even in the non-diabetic range is associated with increased risk of CVD, as indicated by an increased atherogenic index of plasma.
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Glucemia/metabolismo , Enfermedades Cardiovasculares/sangre , Ayuno/sangre , Lípidos/sangre , Adulto , Factores de Edad , Enfermedades Cardiovasculares/diagnóstico , Humanos , Masculino , Persona de Mediana Edad , Estudios Retrospectivos , Factores de RiesgoRESUMEN
In type 2 diabetics, the progression of atherosclerosis is more rapid than the general population and 80% of these patients will die of an atherosclerotic event. Since in these patients hyperglycemia per se confers increased risk for cardiovascular disease (CVD), the presence of even borderline-high-risk LDL-C signals the need for more aggressive LDL-lowering therapy. Most of the lipid lowering agents, currently in use in the treatment of dyslipidemia in type 2 diabetics, have a host of side effects. In contrast, dietary tocotrienols are Vitamin E and have effective lipid lowering property in addition to their potent antioxidant activity. In this study, we have investigated the therapeutic impacts of tocotrienols on serum and lipoprotein lipid levels in type 2 diabetic patients. Based on known tocotrienol rich fraction (TRF)-mediated decrease on elevated blood glucose and glycated hemoglobin A(1C) (HbA(1C)) in diabetic rats, we have also investigated the effect of TRF on these parameters. A randomized, double blind, placebo-controlled design involving 19 type 2 diabetic subjects with hyperlipidemia was used. After 60 days of TRF treatment, subjects showed an average decline of 23, 30, and 42% in serum total lipids, TC, and LDL-C, respectively. The goal in type 2 diabetics is to reduce LDL-C levels < or = 100mg/dl. In the present investigation tocotrienols mediated a reduction of LDL-C from an average of 179 mg/dl to 104 mg/dl. However, hypoglycemic effect of TRF was not observed in these patients because they were glycemically stable and their glucose and HbA(1) levels were close to normal values. In conclusion, daily intake of dietary TRF by type 2 diabetics will be useful in the prevention and treatment of hyperlipidemia and atherogenesis.