RESUMEN
Background: The present study attempted to evaluate the effect of oral gabapentin and acetaminophen for postoperative analgesia in anorectal surgery. Methods: This double-blind clinical trial was carried out on 144 patients who were candidates for anorectal surgery. The patients were randomly assigned into three groups of control, acetaminophen 500 mg, and gabapentin 300 mg for two hours before the surgery. Data on pain severity based on the visual analog scale (VAS) were evaluated and analyzed. Results: The results of the current study indicated that in patients taking acetaminophen and gabapentin tablets before surgery, the amount of postoperative pain decreased, and the amount of decrease in postoperative pain in the patients who received acetaminophen and gabapentin tablets compared with the placebo group was significant (P<0.001). Also, an evaluation was done using a proposed fuzzy logic model. Conclusion: Taking acetaminophen and gabapentin tablets one hour before the operation causes a significant reduction in postoperative pain in patients who are candidates for anorectal surgery. The results are promising and encourage one to pay attention to more studies with the goal of possibly using them as a decision-support model in the future.
RESUMEN
Background: In pediatrics, appendicitis is the leading cause of emergency surgery. It was previously believed that postponing the surgery could lead to the appendix rupture. Children with this condition can be difficult to diagnose. The evidence regarding the necessity of an immediate appendectomy is a topic of debate. In this study, we evaluated the medical records of patients who were diagnosed with acute appendicitis to determine whether postponing appendectomy for one night is safe or not. Methods: This study involved 534 individuals diagnosed with acute appendicitis, who were separated into two groups: those who underwent an appendectomy immediately (within 8 hours) and those who had a delayed procedure (between 8-18 hours). We recorded and compared demographic data, symptoms, laboratory results, time of symptoms, hospitalization duration, surgery duration, overall time, length of stay after surgery, and any other complications that occurred between the two groups. Results: The rate of surgical site infection (SSI) did not differ significantly between the groups (2.8% vs 4.2%, P=0.74). Additionally, there was no significant difference in the risk of perforation between the time of surgery in our study (21.9% vs 19.8%, P>0.05). Conclusion: Our findings suggest that there is no increased risk of complications such as perforation when appendectomy is delayed for up to 18 hours.