RESUMEN
Non-compact right ventricular myocardium is a rare type of cardiomyopathy, it usually results from arrested myocardial development during embryogenesis. This disease can be characterized by excessive prominent trabeculations and deep inter-trabecular recesses in the ventricular wall. It might be a component of biventricular non-compact cardiomyopathy or an isolated form. The article presents a review of the literature on the clinic and radiation diagnostics of non-compact right ventricular myocardium with the presentation of the issues of differential diagnosis.
Asunto(s)
Cardiomiopatías , Ecocardiografía , Humanos , Ventrículos Cardíacos/diagnóstico por imagen , Miocardio , Cardiomiopatías/diagnóstico , Diagnóstico DiferencialRESUMEN
We studied the effect of camphecin (1,7,7-trimethylbicyclo[2.2.1]heptan-2-ylidene-aminoethanol) on mouse behavior in the open-field test. Camphecin possesses antiviral activity and inhibits viral replication, but its influence on the nervous system is poorly studied. Single camphecin injection produced no significant changes in behavioral patterns. Chronic camphecin administration (5 times over 2 weeks) to mice of different strains had no significant influence on open field behavior (motor, exploratory activity, anxiety, emotional state and vegetative functions). The findings are discussed in the context of neutral influence of camphecin on animal behavior.
Asunto(s)
Antivirales/farmacología , Conducta Animal/efectos de los fármacos , Compuestos Bicíclicos con Puentes/farmacología , Etanolaminas/farmacología , Animales , Antivirales/síntesis química , Ansiedad , Conducta Animal/fisiología , Compuestos Bicíclicos con Puentes/síntesis química , Etanolaminas/síntesis química , Conducta Exploratoria/efectos de los fármacos , Conducta Exploratoria/fisiología , Femenino , Masculino , Aprendizaje por Laberinto/efectos de los fármacos , Aprendizaje por Laberinto/fisiología , Ratones , Ratones Endogámicos AKR , Ratones Endogámicos C3H , Ratones Endogámicos C57BL , Ratones Endogámicos CBA , Ratones Endogámicos DBA , Actividad Motora/efectos de los fármacos , Actividad Motora/fisiologíaRESUMEN
We performed a complex functional study of the effects of prostaglandin synthesis blockage with diclofenac on manifestation of the hydroosmotic effect of vasopressin V2-receptor agonist desmopressin in the kidneys of Wistar rats with normal synthesis of endogenous vasopressin and homozygous Brattleboro rats with hereditary impaired synthesis of neurohypophyseal hormone vasopressin. Blockage of prostaglandin synthesis led to more pronounced increase in urine osmolality in Brattleboro rats than in Wistar rats due to elevation of not only urine but also sodium gradient at the expense of elimination of the inhibitory effect of prostaglandins on sodium reabsorption and membrane permeability for urine. During combined treatment, the effects of the hormone predominated: the increase in urine osmolality in Wistar and Brattleboro rats did not differ from that after desmopressin administration.
Asunto(s)
Fármacos Antidiuréticos/farmacología , Diabetes Insípida Nefrogénica/tratamiento farmacológico , Diclofenaco/farmacología , Antagonistas de Prostaglandina/farmacología , Prostaglandinas/biosíntesis , Vasopresinas/farmacología , Animales , Desamino Arginina Vasopresina/farmacología , Diabetes Insípida Nefrogénica/patología , Diabetes Insípida Nefrogénica/orina , Corteza Renal/efectos de los fármacos , Corteza Renal/metabolismo , Corteza Renal/patología , Médula Renal/efectos de los fármacos , Médula Renal/metabolismo , Médula Renal/patología , Concentración Osmolar , Ratas , Ratas Brattleboro , Ratas Wistar , Sodio/orina , Vasopresinas/deficienciaRESUMEN
Ultrastructural changes in cells of the renal inner medulla involved in the realization of the antidiuretic effect of vasopressin under conditions of prostaglandin synthesis blockade were studied in the kidneys of Wistar rats and endogenous vasopressin-deficient homozygous Brattleboro rats. The results indicated uniform trend to an increase in the number of clathrincoated vesicles under conditions of hormone treatment combined with prostaglandin synthesis blockade in animals with different neurohypophyseal status. These changes reflected translocation of aquaporins and an increase in the permeability of the collecting tubular epithelium for water. Brattleboro rats, but not Wistar rats, exhibited ultrastructural signs of synthesis activation in the epithelium and widening of the intercellular gaps, which could indicate more intense paracellular water transport.
Asunto(s)
Fármacos Antidiuréticos/farmacología , Diabetes Insípida Neurogénica/tratamiento farmacológico , Médula Renal/efectos de los fármacos , Túbulos Renales Colectores/efectos de los fármacos , Prostaglandinas/metabolismo , Vasopresinas/farmacología , Animales , Acuaporinas/metabolismo , Transporte Biológico , Vesículas Cubiertas por Clatrina/efectos de los fármacos , Vesículas Cubiertas por Clatrina/metabolismo , Diabetes Insípida Neurogénica/metabolismo , Diabetes Insípida Neurogénica/patología , Diclofenaco/farmacología , Médula Renal/metabolismo , Médula Renal/patología , Túbulos Renales Colectores/metabolismo , Túbulos Renales Colectores/patología , Microscopía Electrónica , Concentración Osmolar , Antagonistas de Prostaglandina/farmacología , Transporte de Proteínas , Ratas , Ratas Brattleboro , Ratas Wistar , Vasopresinas/deficiencia , Agua/metabolismoRESUMEN
We studied ultrastructural features of epithelial cells of the inner medullary collecting tubules in Brattleboro and Wistar under the action of desmopressin (dDAVP, 5 µg/100 g body weight for 2 days). Intracellular reorganization of transepithelial barrier for osmotic water transport depended on the capacity of rats to the synthesis of endogenous vasopressin.
Asunto(s)
Fármacos Antidiuréticos/farmacología , Desamino Arginina Vasopresina/farmacología , Túbulos Renales Colectores/efectos de los fármacos , Animales , Vesículas Cubiertas por Clatrina/efectos de los fármacos , Vesículas Cubiertas por Clatrina/metabolismo , Vesículas Cubiertas por Clatrina/ultraestructura , Células Epiteliales/efectos de los fármacos , Células Epiteliales/ultraestructura , Túbulos Renales Colectores/citología , Túbulos Renales Colectores/metabolismo , Orgánulos/efectos de los fármacos , Orgánulos/ultraestructura , Ratas Brattleboro , Ratas Wistar , Vasopresinas/biosíntesisRESUMEN
We studied the effect of vasopressin V2 receptor agonist (desmopressin, 5 µg/100 g body weight for 2 days) on the efficiency of osmotic concentration in Wistar rats and homozygous Brattleboro rats defective by the synthesis of antidiuretic hormone. Specific differences in the reaction of the osmotic concentration system components (urine osmolality and urea, sodium, and potassium content in the renal tissue) involved in the realization of the hydroosmotic effect of the hormone depend on genetically determined capacity to vasopressin synthesis in these animals.
Asunto(s)
Fármacos Antidiuréticos/farmacología , Desamino Arginina Vasopresina/farmacología , Animales , Médula Renal/efectos de los fármacos , Médula Renal/metabolismo , Concentración Osmolar , Potasio/orina , Ratas Brattleboro , Ratas Wistar , Sodio/orina , Urea/orina , Vasopresinas/fisiologíaRESUMEN
The characteristics of the osmotic concentration system under conditions of sodium diclofenac treatment were studied in Wistar rats with normally functioning vasopressin gene and homozygotic Brattleboro rats completely lacking endogenous vasopressin. Blockade of prostaglandin synthesis in rats with different neurohypophyseal status stimulated urinary osmolality to a different degree. Different contribution of sodium cations and urea to osmotic concentration was revealed.
Asunto(s)
Inhibidores de la Ciclooxigenasa/administración & dosificación , Diclofenaco/administración & dosificación , Riñón/efectos de los fármacos , Neurohipófisis/efectos de los fármacos , Antagonistas de Prostaglandina/administración & dosificación , Animales , Cationes Monovalentes , Riñón/metabolismo , Riñón/fisiopatología , Concentración Osmolar , Neurohipófisis/metabolismo , Neurohipófisis/fisiopatología , Prostaglandinas/metabolismo , Ratas , Ratas Brattleboro , Ratas Wistar , Sodio/orina , Urea/orina , Vasopresinas/deficiencia , Vasopresinas/genética , Equilibrio Hidroelectrolítico/efectos de los fármacosRESUMEN
Morphological characteristics of the inner medullary zone in the kidneys in Brattleboro and Wistar rats were studied during blockade of prostaglandin synthesis. The absence of a diuretic effect of prostaglandins on the kidneys was accompanied by structural changes in the transepithelial and interstitial barriers for an osmotic flow of water.
Asunto(s)
Diabetes Insípida/patología , Médula Renal/patología , Prostaglandinas/biosíntesis , Animales , Forma de la Célula , Diclofenaco/farmacología , Epitelio/enzimología , Epitelio/metabolismo , Epitelio/patología , Matriz Extracelular/metabolismo , Glucuronidasa/metabolismo , Ácido Hialurónico/metabolismo , Capacidad de Concentración Renal/efectos de los fármacos , Médula Renal/enzimología , Médula Renal/metabolismo , Concentración Osmolar , Ratas , Ratas Brattleboro , Ratas Wistar , Vasopresinas/deficienciaRESUMEN
The function and histochemistry of the kidney were studied in homozygous Brattleboro rats after 28-day treatment with exogenous arginine-vasopressin. The long-lasting effect of the hormone includes normalization of osmotic concentration, decrease in the number of b-glucuronidase granules in the medulla, and increasing content of hyaluronan in the interstitium. These changes promote physiological optimization of the antidiuretic reaction to vasopressin.