RESUMEN
Altogether 58 patients suffering from arterial hypertension (AH) were examined. The patients with left ventricular hypertrophy (LVH) and changes in the ST-T demonstrated a high correlation between an increase of the end systolic tension (EST) and interval elongation and the minimal size of the left ventricle before mitral valve opening. These data point to the development of "high-stressful LVH" which is accompanied by a non-proportional increase of EST, subendocardial ischemia of the myocardium (changes in the ST-T) and derangement of diastolic heart function.
Asunto(s)
Electrocardiografía , Hipertensión/diagnóstico , Hipertrofia Ventricular Izquierda/diagnóstico , Adulto , Ecocardiografía , Femenino , Corazón/diagnóstico por imagen , Corazón/fisiopatología , Hemodinámica , Humanos , Hipertensión/etiología , Hipertensión/fisiopatología , Hipertrofia Ventricular Izquierda/etiología , Hipertrofia Ventricular Izquierda/fisiopatología , Masculino , Cintigrafía , Albúmina Sérica RadioyodadaRESUMEN
Intravenous verapamil infusion reduced the arterial pressure (AP) in 13 out of 71 (76.5%) patients with severe arterial hypertension (AH) refractory to a two-week, three-step oral antihypertensive medication. Investigations including echo- and radio-cardiography were performed: in the control period before starting the three-step treatment; after two weeks before intravenous verapamil infusions; 10 days after stopping the verapamil administration, and before leaving the hospital during continued 3-4 weeks three-step therapy. The AP reduction was caused by decreased total peripheral resistance. Verapamil administration improved also intracardiac haemodynamics and left ventricular contraction. The AP was effectively controlled even after stopping the verapamil administration and continuing the three-step oral antihypertensive treatment. No manifest changes in the left ventricular function were registered.
Asunto(s)
Antihipertensivos/administración & dosificación , Hipertensión Renal/tratamiento farmacológico , Hipertensión/tratamiento farmacológico , Verapamilo/administración & dosificación , Adulto , Clonidina/administración & dosificación , Ecocardiografía/efectos de los fármacos , Femenino , Hemodinámica/efectos de los fármacos , Humanos , Hidroclorotiazida/administración & dosificación , Hipertensión/diagnóstico por imagen , Hipertensión Renal/diagnóstico por imagen , Infusiones Intravenosas , Masculino , Metildopa/administración & dosificación , Persona de Mediana Edad , Nifedipino/administración & dosificación , Función Ventricular Izquierda/efectos de los fármacosRESUMEN
A study was undertaken to examine 285 patients with hypertensive disease and 187 with secondary arterial hypertension. Their hemodynamic parameters were assessed by a radionuclide method. It was found that there were various blood circulatory types at each stage, no matter what the clinical type of the disease. The state of central hemodynamics was demonstrated to be associated with interaction of cardiac and peripheral mechanisms responsible for blood circulatory regulation.
Asunto(s)
Hemodinámica , Hipertensión/fisiopatología , Pielonefritis/complicaciones , Adulto , Anciano , Enfermedad Crónica , Femenino , Humanos , Hipertensión/etiología , Masculino , Persona de Mediana EdadRESUMEN
As many as 75 patients with essential hypertension were examined by echocardiography and radiocardiography. The development of hypertrophy was accompanied by the rise of the diastolic dimensions of the left ventricle regardless of the type of the heart overload (by volume or pressure). As left ventricle hypertrophy developed, the myocardial contractility declined and normal hemodynamic function of the heart was maintained due to the Frank-Starling mechanism. The relationship has been established between the intensity of hypertrophy, left ventricle function and the hemodynamic profile of the disease.
Asunto(s)
Adaptación Fisiológica/fisiología , Corazón/fisiopatología , Hipertensión/fisiopatología , Adulto , Cardiomegalia/fisiopatología , Ecocardiografía , Femenino , Ventrículos Cardíacos/fisiopatología , Hemodinámica/fisiología , Humanos , Masculino , Persona de Mediana EdadRESUMEN
The authors presented the results of a combined radionuclide study of the state of pulmonary hemodynamics in patients with essential hypertension. Altogether 132 patients were investigated. Radiocardiography, perfusion scintigraphy and a study of the regional pulmonary blood flow using radioactive Xe were conducted. An analysis of the results has shown that in some patients pulmonary hypertension develops even at early stages of the disease and is particularly marked in stages IIB-III. The mechanism of development of pulmonary hypertension depended at each stage on the interrelationship and time course of indices that characterized pulmonary circulation, and was of different nature. Hemodynamic disorder was manifested in blood mass redistribution from the lower lung regions to the upper ones, slowing down of rate parameters and a raise of pulmonary vascular resistance.
Asunto(s)
Hemodinámica , Hipertensión/fisiopatología , Circulación Pulmonar , Humanos , Hipertensión/diagnóstico por imagen , Cintigrafía , Albúmina Sérica Radioyodada , Agregado de Albúmina Marcado con Tecnecio Tc 99m , Radioisótopos de XenónRESUMEN
Dispensary care was provided to 122 patients with essential hypertension. During a 3-year follow-up period BP decrease in regularly treated patients (44) was accompanied by the restoration of hemodynamic cardiac function and regression of myocardial hypertrophy and ischemia. BP stabilization, transformation of the blood circulation of hemodynamic type, an increased degree of myocardial hypertrophy and ischemia were noted in irregularly treated patients.
Asunto(s)
Antihipertensivos/uso terapéutico , Hipertensión/tratamiento farmacológico , Adulto , Cardiomegalia/diagnóstico , Cardiomegalia/etiología , Cardiomegalia/fisiopatología , Enfermedad Coronaria/diagnóstico , Enfermedad Coronaria/etiología , Enfermedad Coronaria/fisiopatología , Evaluación de Medicamentos , Electrocardiografía , Femenino , Hemodinámica/efectos de los fármacos , Humanos , Hipertensión/complicaciones , Hipertensión/fisiopatología , Masculino , Persona de Mediana Edad , Factores de TiempoRESUMEN
Disorders of left-ventricular diastolic relaxation and blood filling in patients with first- and second-stage essential hypertension are shown, by means of echo-, radio- and apexcardiography, to be due to the effects of arterial blood pressure, hemodynamic changes, heart rate and the magnitude of left-ventricular hypertrophy. Antihypertensive treatment, affecting major parameters of disease, brings about the recovery of the heart's diastolic function.
Asunto(s)
Diástole , Corazón/fisiopatología , Hipertensión/fisiopatología , Contracción Miocárdica , Adulto , Antihipertensivos/uso terapéutico , Cardiomegalia/tratamiento farmacológico , Cardiomegalia/fisiopatología , Diástole/efectos de los fármacos , Femenino , Pruebas de Función Cardíaca , Ventrículos Cardíacos/fisiopatología , Hemodinámica/efectos de los fármacos , Humanos , Hipertensión/tratamiento farmacológico , Masculino , Contracción Miocárdica/efectos de los fármacosRESUMEN
Proceeding from a study of the nature of changes in hemodynamics during development of hypertensive disease (HD) at its different stages it was shown that hemodynamic changes in 42.1% of the patients with Stage I-IIA HD were of hypertensive type, in the patients with Stage IIB-III HD normal and hypokinetic types of the blood circulation prevailed. After bicycle ergometry exercise the reactivity of the cardiovascular system was revealed more completely. The transition of one hemodynamic type into another and its detection acquired a great importance. The definition of the types of hemodynamics at rest and of effort was very important in terms of adequate antihypertensive therapy and the prediction of a subsequent course of disease. The most complete information on function of the cardiovascular system and myocardial contractility can be obtained with the help of radio-angiocardiography and radionuclide ventriculography. However in the absence of a gamma-chamber radiocardiography can provide necessary information on function of the cardiovascular system in case it is used in one and the same patient over time using bicycle ergometry testing.
Asunto(s)
Hipertensión/diagnóstico por imagen , Sistema Cardiovascular/diagnóstico por imagen , Sistema Cardiovascular/fisiopatología , Hemodinámica , Humanos , Hipertensión/fisiopatología , Esfuerzo Físico , Cintigrafía , Albúmina Sérica RadioyodadaRESUMEN
The state of the cerebral blood flow in essential hypertension has been studied in relation to various clinical and hemodynamic parameters. The authors emphasize that the regulation of the cerebral blood flow depends to a great degree on the level of the systolic and pulse pressure as well as on the type of hemodynamics.
Asunto(s)
Circulación Cerebrovascular , Hipertensión/fisiopatología , Adulto , Anciano , Presión Sanguínea , Gasto Cardíaco , Terapia Combinada , Humanos , Hipertensión/terapia , Persona de Mediana Edad , Pulso Arterial , Pertecnetato de Sodio Tc 99m , Radioisótopos de XenónAsunto(s)
Sistema Cardiovascular/fisiopatología , Enfermedad Coronaria/fisiopatología , Prueba de Esfuerzo , Hemodinámica , Albúmina Sérica Radioyodada , Adulto , Presión Sanguínea , Volumen Sanguíneo , Gasto Cardíaco , Humanos , Pulmón/irrigación sanguínea , Persona de Mediana Edad , Resistencia VascularRESUMEN
A total of 120 patients with essential hypertension, stage I and II, were examined, using radio- and electrocardiography, before and after a hypotensive treatment. Two mechanisms: excessive volume (in patients with hyperkinetic circulation) and excessive pressure (in those with normo- and hypokinetic circulation) were found to form the basis of the formation of left-ventricular muscular hypertrophy. Antihypertensive effect of treatment reducing electrocardiographic signs of left-ventricular muscular hypertrophy was shown to be related to improved arterial pressure control and lesser adrenergic influence on the heart.