RESUMEN

We tested the ability of cellularly cloned Rauscher helper leukemia virus to modulate the release of hemopoietic regulatory activities by skin fibroblasts in culture. The results demonstrate that release of colony stimulating activity for granulocyte/macrophage progenitors by fibroblasts derived from BALB/c, NIH/RIV, 129/J, and DBA/2 mice was increased by virus infection. In contrast, virus infection severely impaired the ability of fibroblasts to support in-vitro granulopoiesis.

Asunto(s)

Factores Estimulantes de Colonias/metabolismo , Fibroblastos/metabolismo , Virus Helper/fisiología , Hematopoyesis , Virus Rauscher/fisiología , Animales , Células de la Médula Ósea , Femenino , Fibroblastos/microbiología , Granulocitos , Macrófagos , Masculino , Ratones , Ratones Endogámicos