RESUMEN
Cardanol is a constituent of Cashew Nut Shell Liquid that presents larvicidal activity against Aedes aegypti. The isolation of cardanol is somewhat troublesome, however, in this work we describe an efficient and inexpensive method to obtain it as a pure material. The compound was used as starting material to make chemical transformation leading to saturated cardanol, epoxides and, halohydrins. These derivatives were tested for toxicity against Aedes aegypti larvae. The results showed that iodohydrins are very promising compounds for making commercial products to combat the vector mosquito larvae presenting a LC50 of 0.0023 ppm after 72 h of exposure.
Asunto(s)
Aedes/efectos de los fármacos , Insecticidas/farmacología , Fenoles/farmacología , Animales , Insecticidas/síntesis química , Insecticidas/toxicidad , Larva/efectos de los fármacos , Dosificación Letal Mediana , Fenoles/química , Fenoles/aislamiento & purificación , Fenoles/toxicidad , Factores de TiempoRESUMEN
ABSTRACT Cardanol is a constituent of Cashew Nut Shell Liquid that presents larvicidal activity against Aedes aegypti. The isolation of cardanol is somewhat troublesome, however, in this work we describe an efficient and inexpensive method to obtain it as a pure material. The compound was used as starting material to make chemical transformation leading to saturated cardanol, epoxides and, halohydrins. These derivatives were tested for toxicity against Aedes aegypti larvae. The results showed that iodohydrins are very promising compounds for making commercial products to combat the vector mosquito larvae presenting a LC50 of 0.0023 ppm after 72 h of exposure.
Asunto(s)
Animales , Fenoles/farmacología , Aedes/efectos de los fármacos , Insecticidas/farmacología , Fenoles/aislamiento & purificación , Fenoles/toxicidad , Fenoles/química , Factores de Tiempo , Insecticidas/síntesis química , Insecticidas/toxicidad , Larva/efectos de los fármacos , Dosificación Letal MedianaRESUMEN
Lipases from different sources, Pseudomonas fluorescens (AK lipase), Burkholderia cepacia (PS lipase), Penicillium camembertii (lipase G) and Porcine pancreas lipase (PPL), previously immobilized on epoxy SiO(2)-PVA, were screened for the synthesis of xylitol monoesters by esterification of the protected xylitol using oleic acid as acyl donor group. Among all immobilized derivatives, the highest esterification yield was achieved by P. camembertii lipase, showing to be attractive alternative to bulk chemical routes to satisfy increasing commercial demands. Further experiments were performed to determine the influence of fatty acids chain size on the reaction yield and the feasibility of using non-conventional heating systems (microwave and ultrasound irradiations) to enhance the reaction rate.