RESUMEN
Diagnosis is suggested by the functional symptoms and digital rectal examination and must be confirmed by histological examination. The second step is to evaluate the patient's condition, the extent of the cancer and the consequences on the urinary system; the choice of the treatment depends on this evaluation. The most common tumors are adenocarcinomas with a histological grading strongly correlated to the lymphatic involvement and frequency of metastases. Lymphatic involvement is closely related to the local clinically demonstrable involvement, histological grade, serum acid phosphatase concentrations and results of lymphography. Upon diagnosis of cancer of the prostate more than half the patients already harbour metastases, usually of the bone. This percentage is correlated to the size of the primary tumor, involvement of the seminal vesicles, histological grade and lymphatic involvement. The authors propose a series of investigations adapted to each case.
Asunto(s)
Adenocarcinoma/diagnóstico , Neoplasias de la Próstata/diagnóstico , Adenocarcinoma/patología , Anciano , Humanos , Metástasis Linfática , Masculino , Persona de Mediana Edad , Invasividad Neoplásica , Metástasis de la Neoplasia , Estadificación de Neoplasias , Neoplasias de la Próstata/patologíaRESUMEN
Intrahypothalamic implants of testosterone propionate (TP), 5 alpha-dihydrotestosterone (DHT) and estradiol (E) were compared for their effectiveness in reactivating sexual behavior of castrated male golden hamsters. Males tested preexperimentally and then observed for loss of sexual behavior responses after long-term castration were divided into four experimental treatment groups: anterior TP implants, DHT implants and E implants, and posterior TP implants. All animals were tested at 7 and 21 days postimplantation. On the day 7 implant test mount frequency, latency and duration per mount were significantly different from the castrate response for the TP implant groups. On the day 21 implant test both TP and E implant groups showed significant changes in mounting while intromission frequency, latency and duration per intromission were significantly different from the castrate only for the TP implant groups. DHT implants were not effective in reactivating any aspect of copulatory behavior in the castrate male hamster.