RESUMEN
Histoautoradiographic procedures were employed to establish the level of cell proliferation in gastric epithelium, using biopsy material from 84 patients suffering from gastritis--59 cases (superficial)--10, glandular lesions other than atrophy--18, mild atrophy--13, moderate atrophy--11, severe atrophy--7), 17 cases of peptic ulcer and 8 patients with adenomatous polyposis. Cell proliferation level in patients with peptic ulcer and polyps was identical to those in cases of non-atrophic gastritis or mild atrophy of mucosa. In cases of gastritis, the rise in cell proliferation is matched by the advancement of atrophic changes and reaches its peak in patients with severe atrophic gastritis. It is suggested that chronic gastritis involving pronounced atrophy of mucosa constitutes the most important factor of risk of cancer among the other precancerous lesions of the stomach.
Asunto(s)
ADN de Neoplasias/biosíntesis , Lesiones Precancerosas/metabolismo , Neoplasias Gástricas/metabolismo , Autorradiografía , Transformación Celular Neoplásica/metabolismo , ADN/biosíntesis , Epitelio/metabolismo , Gastritis/metabolismo , Humanos , Pólipos/metabolismo , Úlcera Gástrica/metabolismoRESUMEN
One hundred and fourty seven lymph nodes involved by metastases of the stomach, breast and lung cancer have been examined. It was found that in metastatic stomach cancer the PAS-reaction intensity is high, the mitotic level is low, the modal class of cells on the histogram is diploid. Breast cancer metastases are characterized by weak PAS-reaction, distinct stroma and cell reaction around the tumor, the prevalence of tetroploid nuclei on the histogram. In lung cancer metastases the PAS-positive substances are practically absent, the stroma and cell-reaction around the tumor is less distinct, the mitotic level is high, the number of hypodiploid nuclei on the histogram is 10.4%. Based on the data obtained histographically the author suggests a new criterion -- a coefficient of stability/a ratio of the diploid nuclei number to the number of the rest ones/ which allows a quantitative characterization of the intensity of the nuclei polymorphism in tumors.