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BACKGROUND Hepatitis C virus (HCV) is considered to be the major cause of post-transfusion hepatitis in patients with thalassemia. We aimed to determine the HCV prevalence, genotypes, and viral load among patients with major ß-thalassemia in Mashhad, Iran. METHODS Medical records of all 550 patients with major ß-thalassemia who referred to ThalassemiaHemophilia Center of Mashhad (Sarvar Clinic) were reviewed from October to November 2011. Plasma samples of the patients were tested for the presence of anti-HCV antibodies by enzyme linked immunosorbent assay. Real-time polymerase chain reaction (PCR) was used to determine viral genotype and HCV RNA titer. RESULTS HCV antibodies were detected in 37 individuals (6.73%) including 17 men and 20 women with mean age of 25.2 ± 8.4 years. The PCR analysis was performed for 27 patients, of whom HCV RNA was detected in 17 patients (63.0%). Viral titers were investigated in 14 subjects and a high viral load more than 600000 copies/mL was observed in 6 patients (42.9%). The most prevalent genotypes were 3a (50.0%) followed by 1a (37.5%). No significant correlation was found between genotype and age, sex, serum ferritin, liver tests, and HCV RNA titer. CONCLUSION HCV infection among patients with thalassemia is more common than general population in Mashhad, northeast Iran. The dominant HCV subtype is 3a followed by 1a. These findings could help health authorities to provide preventive measures, and practitioners to choose the right protocol of treatment for the patients.
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INTRODUCTION: The main objective of this study was to determine the mental health status of population aged 15 and over in the province of Ardebil in 2015. METHODS: The statistical population of this cross-sectional field survey consisted of residents of urban and rural areas of Ardebil province in Iran. An estimated sample size of 1200 people were chosen using systematic random cluster sampling. Access was provided by the contribution of Geographical Post Office of Ardebil, Pars abad and Germi cities. The General Health Questionnaire-28 (GHQ-28) was used as the screening tool for mental disorders. Data analysis in the current study was carried out using the SPSS-18 software. RESULTS: Using GHQ traditional scoring method, the results showed that 21.4% of individuals (26.3% of females and 16.5% of males) were suspected of mental disorders. The prevalence of suspected cases of mental disorders was 20.8% in urban and 22.8% in rural areas. The results also showed that somatization and anxiety symptoms were more prevalent than social dysfunction and depression symptoms, and were more common in women than men. The results of this research also showed that the prevalence of suspected cases of mental disorders increased with aging. Such disorders were more common in females, age group of 65 and above, people living in rural areas, divorced and widowed, illiterate and unemployed individuals compared with other groups. CONCLUSION: The results of this study showed that about one fifth of people in the province were suspected of mental disorders. Therefore, it is mandatory for the provincial public health authorities to take the needed steps to ensure that necessary requirements encompassing prevention and promotion of mental health are implemented.