RESUMEN
The prospect of using the antioxidant dipeptide carnosine for the treatment of urate nephrolithiasis was evaluated. Urate nephrolithiasis was modeled in rats by intragastric administration of a mixture of oxonic and uric acids. Carnosine was administered intragastrically through a tube in a dose of 15 mg/kg. In rats treated with carnosine, the concentration of TBA-reactive products decreased by 1.4 times, the total antioxidant activity increased by 1.4 times, and catalase activity increased by 1.3 times. By the end of the experiment, the lactate dehydrogenate level in experimental rats was 2-fold lower than in the control, and the number of urate deposits decreased by 1.6 times with a concomitant alleviation of the inflammatory processes. Thus, the use of direct peptide antioxidant carnosine attenuated the manifestations of urate nephrolithiasis.
Asunto(s)
Carnosina/farmacología , Riñón/efectos de los fármacos , Nefrolitiasis/patología , Animales , Antioxidantes/farmacología , Antioxidantes/uso terapéutico , Carnosina/uso terapéutico , Modelos Animales de Enfermedad , Progresión de la Enfermedad , Radicales Libres/metabolismo , Riñón/metabolismo , Riñón/patología , Masculino , Nefrolitiasis/tratamiento farmacológico , Nefrolitiasis/metabolismo , Estrés Oxidativo/efectos de los fármacos , Ratas , Ratas Wistar , Ácido Úrico/metabolismoRESUMEN
Screening tests on mice with the use of a model of neurogenic damage to the stomach revealed antiulcerative activity in extracts of Amoor cork tree, Pacific Bergenia, Lespedeza dichromatic, Leuzea carthamoides, sea-buckthorn, common aspen, Manchurian nuts, Serratula coronarius, and Scutellaria baicalensis. It was proved that an extract of aspen cork produces a marked antiulcerative effect on being administered to animals with "acute" ulcers and in treatment of chronic peptic ulcer. The study of various drug forms of Serratula coronarius extracts (prepared from the bark and the bark and shoots) in experiments on mice (neurogenic ulcer) and rats (Aspirin ulcer) revealed the most marked gastroprotective effect of oil extracts of bark and shoots. A high antiulcerogenic activity of extracts prepared from grass and roots of Scutellaria baicalensis was demonstrated.