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Our study aimed at the reliability and validity of the Persian version of the Adolescent/Adult Sensory Profile (AASP). This study was conducted on 130 people with dementia as well as 77 healthy elderlies. After translating the AASP into Persian, its content validity was determined based on 9 experts working in the same field. Cronbach's alpha and the Intraclass correlation coefficient (ICC) were calculated to assess the internal consistency and test-retest reliability of the Persian version of AASP. The two groups of people with dementia and healthy elderlies were compared in terms of scores in the four quadrants by performing an Independent t-test. All items in the Content Validity Ratio (CVR) and Content Validity Index (CVI) received an acceptable score. The Cronbach's alpha score for different parts of AASP was also calculated (α between 0.894 and 0.916; p < 0.001). The test-retest reliability of sub-tests of AASP was excellent (ICC between 0.885 and 0.948; p < 0.001). There was a statistically significant difference between the healthy Elderlies and dementia persons for low registration, sensory avoiding quadrants (p < 0.05). The Persian version of the AASP questionnaire is a reliable and valid questionnaire for people with dementia in Iran.
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Demencia , Traducciones , Adulto , Humanos , Adolescente , Reproducibilidad de los Resultados , Psicometría , Traducción , Encuestas y Cuestionarios , Irán , Demencia/diagnósticoRESUMEN
OBJECTIVES: Sensory processing and sleep quality affect children's academic performance and their quality of life. This study aimed to investigate the relationship between sensory processing patterns and sleep quality in primary school children. MATERIALS & METHODS: In this cross-sectional study, 231 primary school students aged 7 to 12 years old (133 girls and 98 boys, the mean age of 8.68±1.51) who were studying in schools in Tehran were randomly selected through cluster sampling. The researchers distributed a questionnaire on children's sleep habits to assess the quality of sleep and a sensory profile questionnaire to assess the sensory processing patterns (avoidance, sensitivity, seeking, and registration) among the students. RESULTS: In this study, we found a meaningful moderate relationship between sensory processing patterns and overall scores of sleep habits (p <0.001). Moreover, each of the sensory processing patterns had a negative relationship with areas of sleep habits (p = 0.005). There was also a significant difference between children who had more challenges with sleep maintenance and children with normal sleep patterns in sensory processing; mean differences were significant in all the four sensory quadrants (registration, seeking, sensitivity, and avoiding) (p <0.001). CONCLUSION: The sensory processing patterns are moderately correlated with sleep habits in primary school children. Occupational therapists and other specialists working in the field of children's sleep should consider the relationship between sensory challenges and sleep habits while making decisions about sensory challenges and sleep problems. Better sleep may occur with attention to sensory needs in sleep routines. Better sleep may lead to improved quality of life in families and enhanced student performance at school.
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OBJECTIVES: We investigated the effects of a manualized Contextual Intervention adapted for Autism Spectrum Disorders (CI-ASD), and essential elements of the intervention in promoting children's participation and mothers' parenting self-efficacy. MATERIALS & METHODS: In this randomized controlled trial, conducted in Tehran, Iran in 2017, participants (36 parents of children with ASD) were randomly assigned to wait-list control or intervention groups. The intervention comprised contextually reï¬ective occupational therapy combines 3 elements: sensory processing patterns, coaching, and social support. We provided the program to promote child's participation and parent's efficiency. During phase 1, the participants in the intervention group received CI-ASD as long as Treatment As Usual (TAU) and during phase 2 they received TAU only. We completed the outcome measures at three-time points (pre-intervention, post-intervention, and follow-up). We conducted semi-structured interviews post-intervention to explore acceptability of intervention and participants' experiences of CI-ASD. RESULTS: CI-ASD can produce meaningful effects in eliminating sensory issues, promoting child participation and parenting efficiency in ASD families, compared to TAU. Parents reported high levels of acceptance and also confirmed the family's achievements. CONCLUSION: These gains suggest CI-ASD as an effective intervention for children who have ASD and their families, but further studies are needed to declare and generalize the findings over time. Estimated effect sizes were in the large and medium ranges and favored the intervention group.
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AIMS AND OBJECTIVES: This study aims to determine whether children with Autism Spectrum Disorder (ASD) are capable of learning a motor skill both implicitly and explicitly. METHODS: In the present study, 30 boys with ASD, aged 7-11 with IQ average of 81.2, were compared with 32 typical IQ- and age-matched boys on their performance on a serial reaction time task (SRTT). Children were grouped by ASD and typical children and by implicit and explicit learning groups for the SRTT. RESULTS: Implicit motor learning occurred in both children with ASD (p=.02) and typical children (p=.01). There were no significant differences between groups (p=.39). However, explicit motor learning was only observed in typical children (p=.01) not children with ASD (p=.40). There was a significant difference between groups for explicit learning (p=.01). DISCUSSION: The results of our study showed that implicit motor learning is not affected in children with ASD. Implications for implicit and explicit learning are applied to the CO-OP approach of motor learning with children with ASD.
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Trastorno del Espectro Autista/fisiopatología , Aprendizaje/fisiología , Destreza Motora/fisiología , Estudios de Casos y Controles , Niño , Humanos , Masculino , Tiempo de ReacciónRESUMEN
The aim of this study was to investigate the applicability of microspheres containing protease inhibitor for oral delivery of insulin (CAS 9004-10-8). Microspheres of insulin were prepared by water-in-oil-in-oil (w/o1/o2) double emulsion solvent evaporation method. Formulations with different drug/polymer ratios were prepared and characterized by drug loading, loading efficiency, yield, particle size, scanning electron microscopy (SEM), Fourier Transform Infrared spectroscopy (FTIR). The in vitro release studies were performed in pH 1.2 and 7.4. In vivo studies on rats were conducted in order to investigate the bioavailability and performance of oral microspheres. The best polymer to drug ratio in microspheres was 15.6:1 (F2 formulation). The loading efficiency was 77.36%, production yield was 54.55% and mean particle size was 222.4 microm. SEM studies showed that the microspheres were spherical and porous in nature. Data obtained from in vitro release were fitted to various kinetic models and high correlation was obtained in the first order model. The results of enzymatic degradation indicated that insulin could be protected from trypsinic degradation in the microspheres. Our results indicate that the microspheres containing aprotinin (CAS 9087-70-1) have the advantage of high loading efficiency, pH responsive and prolonged release carrying insulin to the optimum site of absorption as well as the enhanced insulin absorption and biological response.
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Hipoglucemiantes/uso terapéutico , Insulina/uso terapéutico , Inhibidores de Proteasas/farmacología , Animales , Área Bajo la Curva , Disponibilidad Biológica , Química Farmacéutica , Dicroismo Circular , Diabetes Mellitus Experimental/tratamiento farmacológico , Portadores de Fármacos , Emulsiones , Hipoglucemiantes/administración & dosificación , Hipoglucemiantes/química , Insulina/administración & dosificación , Insulina/química , Absorción Intestinal , Cinética , Masculino , Microscopía Electrónica de Rastreo , Microesferas , Tamaño de la Partícula , Pepsina A/química , Conformación Proteica , Conejos , Ratas , Ratas Wistar , Espectroscopía Infrarroja por Transformada de Fourier , Tripsina/químicaRESUMEN
Insulin is a polypeptide hormone and usually administered for treatment of diabetic patients subcutaneously. The aim of this study was to investigate the efficiency of enteric nanoparticles for oral delivery of insulin. Nanoparticles were formed by complex coacervation method using chitosan of various molecular weights. Nanoparticles were characterized by drug loading efficiency determination, particle size analysis, Scanning Electron Microscopy (SEM), Zeta potential and CD spectroscopy (Circular Dichrosim). The in vitro release studies were performed at pH 1.2 and 7.4. The drug loaded nanoparticles showed 3.38% of entrapment, loading efficiency of 30.56% and mean particle size of 199 nm. SEM studies showed that the nanoparticles are non-spherical. Zeta potential increased with increasing molecular weight of chitosan. The CD spectroscopy profiles indicated that the nano-encapsulation process did not significantly disrupt the internal structure of insulin; additionally, pH-sensitivity of nanoparticles was preserved and the insulin release was pH-dependent. These results suggest that the complex coacervation process using chitosan and Eudragit L100-55 polymers may provide a useful approach for entrapment of hydrophilic polypeptides without affecting their conformation.