RESUMEN

Successful treatment of a patient with myelokathexis, a rare form of chronic neutropenia associated with recurrent infections, is described. Rapid mobilization of bone marrow neutrophils and improved myeloid morphologic features were observed after treatment with human granulocyte colony stimulating factor. Transient thrombocytopenia and bone pain were observed during treatment. Although neutrophil chemotaxis, superoxide production, and FcRIII surface expression were reduced, the patient improved clinically after restoration of a normal neutrophil count.

Asunto(s)

Factor Estimulante de Colonias de Granulocitos/uso terapéutico , Neutropenia/terapia , Antígenos CD/análisis , Quimiotaxis de Leucocito , Niño , Enfermedad Crónica , Femenino , Gingivitis/inmunología , Gingivitis/terapia , Factor Estimulante de Colonias de Granulocitos/efectos adversos , Humanos , Neutropenia/inmunología , Neutrófilos/metabolismo , Neutrófilos/fisiología , Recuento de Plaquetas , Proteínas Recombinantes/efectos adversos , Proteínas Recombinantes/uso terapéutico , Estomatitis/inmunología , Estomatitis/terapia