Asunto(s)
Lepra Dimorfa/patología , Lepra Tuberculoide/patología , Psoriasis/patología , Adulto , Humanos , Lepra Dimorfa/complicaciones , Lepra Dimorfa/tratamiento farmacológico , Lepra Tuberculoide/complicaciones , Lepra Tuberculoide/tratamiento farmacológico , Masculino , Psoriasis/complicaciones , Psoriasis/tratamiento farmacológicoRESUMEN
This case has been presented as pellagra, which is very rare in children. Pellagra is due dietary deficiency of niacin. Usually seen in alcoholics, malabsorption syndromes occur very rarely in children. A 11-y-old girl presented with well-defined, hyperpigmented, hyperkeratotic, symmetrical, thick scaly plaques surrounded by erythema on the dorsum of the hands, arms, feet, legs up to knees, and along the sides of the neck. The child was given 100 mg of Nicotinamide. Skin lesions resolved rapidly with the treatment and the child improved.
Asunto(s)
Niacina/deficiencia , Pelagra/diagnóstico , Pelagra/tratamiento farmacológico , Niño , Eritema/fisiopatología , Femenino , Humanos , Síndromes de Malabsorción/complicaciones , Síndromes de Malabsorción/tratamiento farmacológico , Niacinamida/uso terapéutico , Pelagra/complicaciones , Enfermedades de la Piel/diagnóstico , Enfermedades de la Piel/tratamiento farmacológico , Enfermedades de la Piel/etiologíaRESUMEN
OBJECTIVE: Cutaneous drug reactions are the most common type of adverse drug reactions. Adverse cutaneous drug reactions form 2-3% of the hospitalized patients. 2% of these are potentially serious. This study aims to detect the drugs commonly implicated in Steven Johnson Syndrome-Toxic Epidermal Necrosis (SJS-TEN). MATERIALS AND METHODS: A retrospective analysis was done in all patients admitted in the last five years in SDM hospital with the diagnosis of SJS-TEN. RESULTS: A total of 22 patients with SJS-TEN were studied. In 11 patients anti-epileptics was the causal drug and in 7, anti-microbials was the causal drug. Recovery was much faster in case of anti epileptics induced SJS-TEN as compared to that induced by ofloxacin. CONCLUSION: SJS-TEN induced by ofloxacin has a higher morbidity and mortality compared to anti convulsants.
Asunto(s)
Antibacterianos/efectos adversos , Anticonvulsivantes/efectos adversos , Ofloxacino/efectos adversos , Síndrome de Stevens-Johnson/inducido químicamente , Síndrome de Stevens-Johnson/etiología , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Niño , Preescolar , Femenino , Humanos , India , Lactante , Masculino , Persona de Mediana Edad , Estudios Retrospectivos , Adulto JovenRESUMEN
Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome is a rare and life-threatening delayed drug hypersensitivity reaction characterized by skin eruption, fever, lymphadenopathies, and visceral involvement. Here, we are presenting a 12 year old boy, who developed rare but life threatening DRESS syndrome due to Lamotrigine. Early detection and treatment led to his rapid recovery. This case is presented to highlight the importance of early detection of rare fatal syndrome.
Asunto(s)
Anticonvulsivantes/efectos adversos , Hipersensibilidad a las Drogas/etiología , Eosinofilia/inducido químicamente , Hipersensibilidad Tardía/inducido químicamente , Triazinas/efectos adversos , Niño , Humanos , Lamotrigina , Masculino , SíndromeRESUMEN
Fixed drug eruption (FDE) is mainly characterized by skin lesions that recur at the same anatomic sites upon repeated exposures to an offending agent. It represents the most common cutaneous adverse drug reaction pattern in Indian patients. Here, we report an FDE to fluconazole.