RESUMEN
(+/-) 15 alpha-OH-11-deoxyprostaglandin E1 was found to possess a pronounced antisecretory activity at stimulation of gastric secretion in cats with pentagastrin. In rats the compound exerted the protective effect of cells of the gastric mucosa, especially on indomethacin and stress models of ulcerogenesis. The cytoprotective effect of the compound seemed to be related to its action on secretion of mucus as well as to its stimulation of zinc accumulation in cells that stabilized cell membranes and suppressed the secretory activity of mast cells.
Asunto(s)
Alprostadil/análogos & derivados , Antiulcerosos/uso terapéutico , Mucosa Gástrica/efectos de los fármacos , Prostaglandinas E Sintéticas/uso terapéutico , Alprostadil/uso terapéutico , Animales , Gatos , Relación Dosis-Respuesta a Droga , Evaluación Preclínica de Medicamentos , Mucosa Gástrica/metabolismo , Indometacina , Masculino , Pentagastrina/farmacología , Ratas , Reserpina , Úlcera Gástrica/tratamiento farmacológico , Úlcera Gástrica/etiología , Estrés Fisiológico/complicacionesRESUMEN
Pentagastrin is found to be a highly active stimulator of the gastric glands secretion. With its intraperitoneal introduction to albino rats the drug displays a low acute toxicity. On its re-administration to rabbits and albino rats in doses significantly exceeding the diagnostic ones no substantial influence on the growth of the animals, hematological, enzymological, proteinological blood indices and morphological condition of internal organs was noted.