Asunto(s)
Exposición por Inhalación/efectos adversos , Polen/inmunología , Rinitis Alérgica Estacional/epidemiología , Árboles/inmunología , Salud Urbana , Adulto , Femenino , Humanos , Pruebas Intradérmicas , Masculino , Persona de Mediana Edad , Valor Predictivo de las Pruebas , Prevalencia , Estudios Prospectivos , Rinitis Alérgica Estacional/diagnóstico , Rinitis Alérgica Estacional/inmunología , España/epidemiologíaRESUMEN
INTRODUCTION: Egg allergy is an adverse immune-system reaction of an IgE-mediated type, which can happen in children after egg intake and several times after their first egg intake. OBJECTIVES: Compare the results of the oral egg-challenge test in two groups of egg-sensitised children, with and without prior intake. PATIENTS AND METHODS: Retrospective study of two egg-sensitised groups (72 subjects). Group 1: 22 children without prior egg-intake. Group 2: 50 children with a clinical history of adverse reactions after egg intake. Skin prick tests, egg-white specific IgE (sIgE) and yolk specific IgE, were performed on all children. The oral egg-challenge tests were performed after a period of egg-avoidance diet and when egg-white specific IgE levels were lower than 1.5K U/L. RESULTS: 31.8% of the children in Group 1 did not tolerate egg-intake whereas 38% of the children in Group 2 did not tolerate egg-intake. Egg-avoidance periods lasted 19.5 and 18 months, respectively. Egg-white specific IgE levels went down in both groups after an egg-avoidance diet. No statistically significant differences were found between the groups and the positivity of oral egg-challenge test. CONCLUSIONS: No statistically significant differences were found in the behaviour of the two groups studied. Given the high risk of adverse reactions, it was recommended that any egg-introduction tests were to be performed in a hospital environment on the children who were sensitised to hen's egg (including children without prior egg intake).
Asunto(s)
Ingestión de Alimentos , Hipersensibilidad al Huevo/diagnóstico , Muramidasa/inmunología , Administración Oral , Alérgenos/efectos adversos , Niño , Preescolar , Hipersensibilidad al Huevo/sangre , Hipersensibilidad al Huevo/inmunología , Hipersensibilidad al Huevo/fisiopatología , Huevos/efectos adversos , Femenino , Humanos , Inmunización , Inmunoglobulina E/sangre , Lactante , Masculino , Pruebas CutáneasAsunto(s)
Trasplante de Riñón/estadística & datos numéricos , Diálisis Renal/estadística & datos numéricos , Adolescente , Adulto , Distribución por Edad , Anciano , Femenino , Humanos , Trasplante de Riñón/mortalidad , Masculino , Persona de Mediana Edad , Diálisis Renal/mortalidad , Distribución por Sexo , España/epidemiologíaAsunto(s)
Fallo Renal Crónico/terapia , Trasplante de Riñón , Sistema de Registros , Diálisis Renal , Adolescente , Adulto , Anciano , Humanos , Fallo Renal Crónico/epidemiología , Trasplante de Riñón/estadística & datos numéricos , Persona de Mediana Edad , Diálisis Renal/estadística & datos numéricos , España/epidemiologíaAsunto(s)
Trasplante de Riñón/estadística & datos numéricos , Sistema de Registros , Diálisis Renal/estadística & datos numéricos , Adolescente , Adulto , Anciano , Niño , Preescolar , Humanos , Incidencia , Lactante , Fallo Renal Crónico/epidemiología , Fallo Renal Crónico/etiología , Fallo Renal Crónico/terapia , Persona de Mediana Edad , Prevalencia , EspañaRESUMEN
BACKGROUND: Atopic dermatitis (AD) is a chronic inflammatory skin disease that frequently precedes the development of asthma or other respiratory allergies. The aim of this study was to review allergen sensitization, type of feeding in infancy, and development of asthma or rhinitis in a group of patients with AD. METHODOLOGY: One hundred children with AD were selected. All patients underwent skin prick and patch tests to foodstuffs and inhalant allergens, total and specific IgE determination, and oral challenge tests. RESULTS: The study included 57 boys and 43 girls. The mean age at consultation was 3.77 +/- 2.81 years and mean age at onset of of AD was 1.09 +/- 1.69 years. Twenty-eight percent of the children were exclusively sensitized to food allergens, 20% to inhalant allergens and 22% to both food and inhalant allergens. Mean serum IgE levels were higher in children sensitized to Dermatophagoides pteronyssinus (DPT) (346.86 +/- 430.43 U/ml) than in non-sensitized children (78.24 +/- 132.93 U/m) (p < 0.001). Total IgE levels were also higher in patients with respiratory symptoms (283.77 +/- 336.53 U/ml) than in children without respiratory disease (124.62 +/- 285.21 U/ml) (p = 0.021). Thirty-five percent of the children developed some kind of respiratory allergic disease (asthma and/or rhinitis) in a mean interval of 2.55 years after the onset of dermatitis. Of the children sensitized to inhalant allergens (DPT), 55.26 % developed respiratory symptoms compared with 22.58 % of the non-sensitized children (p < 0.001). The odds ratio of developing respiratory allergy if the patient showed sensitization to DPT was 4.235 (95 % CI 1.768-0.147, p = 0.002). CONCLUSIONS: Children with AD that develops in the first year of life, associated with high IgE levels and early sensitization, independently of the kind of feeding, develop respiratory allergic disease more frequently than children without these factors.
Asunto(s)
Dermatitis Atópica/epidemiología , Hipersensibilidad Respiratoria/epidemiología , Alérgenos/efectos adversos , Animales , Niño , Preescolar , Dermatitis Atópica/inmunología , Femenino , Hipersensibilidad a los Alimentos/epidemiología , Hipersensibilidad a los Alimentos/inmunología , Humanos , Inmunoglobulina E/sangre , Incidencia , Lactante , Alimentos Infantiles/efectos adversos , Masculino , Ácaros/inmunología , Hipersensibilidad Respiratoria/inmunología , Estudios Retrospectivos , Pruebas Cutáneas , España/epidemiologíaAsunto(s)
Trasplante de Riñón/estadística & datos numéricos , Diálisis Peritoneal/estadística & datos numéricos , Diálisis Renal/estadística & datos numéricos , Adolescente , Adulto , Distribución por Edad , Anciano , Enfermedades Cardiovasculares/mortalidad , Niño , Preescolar , Femenino , Salud Global , Humanos , Incidencia , Lactante , Infecciones/mortalidad , Enfermedades Renales/complicaciones , Enfermedades Renales/epidemiología , Fallo Renal Crónico/epidemiología , Fallo Renal Crónico/etiología , Fallo Renal Crónico/terapia , Trasplante de Riñón/mortalidad , Masculino , Persona de Mediana Edad , Neoplasias/mortalidad , Diálisis Peritoneal/mortalidad , Prevalencia , Sistema de Registros , Diálisis Renal/mortalidad , Estudios Retrospectivos , Sociedades Médicas , España , Encuestas y CuestionariosRESUMEN
A retrospective study of the patients admitted during the last 8 years with status asthmaticus is reported. We compare the requirement of mechanical ventilation with the beta-agonist therapy received and the type of asthma. About 71 patients admitted, 67% were IgE dependent asthmatic (EDA) children and 31% no-IgE dependent asthmatic (nEDA) ones. They needed intermittent positive pressure ventilation (IPPV) in 20 instances; no difference was found between both types of asthma. We studied the ventilatory parameters used. The 33% of EDA children was treated using a continuous IV infusion of hexoprenalina, requiring IPPV in 5 (31%) of them. The rest received a continuous IV of isoproterenol, and only the 16% required IPPV. We found isoproterenol to be more effective than hexoprenalina in the treatment of status asthmaticus. Similar results were obtained with the nEDA group. The Downes score was showed to be a good predictor-index scoring system in many cases.
Asunto(s)
Asma/tratamiento farmacológico , Broncodilatadores/uso terapéutico , Isoproterenol/uso terapéutico , Estado Asmático/tratamiento farmacológico , Adolescente , Broncodilatadores/administración & dosificación , Niño , Preescolar , Terapia Combinada , Evaluación de Medicamentos , Femenino , Hexoprenalina/uso terapéutico , Humanos , Lactante , Inyecciones Intravenosas , Ventilación con Presión Positiva Intermitente , Isoproterenol/administración & dosificación , Masculino , Estudios Retrospectivos , Estado Asmático/terapiaRESUMEN
The latencies of evoked potentials recorded at different levels of the peripheral and central nervous system by median nerve stimulation were measured before and after dialysis, and compared with similar recordings in normal volunteers. Abnormally slow conduction velocity was more often found in proximal rather than in distal segments of the peripheral pathway in patients with chronic renal failure. This abnormality was not correlated with the presence of clinical signs of neuropathy or low values of motor conduction velocity, neither was it affected by dialysis. These findings support the hypothesis of peripheral nerve dysfunction secondary to metabolic derangement in uraemic patients.