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1.
Sci Prog ; 104(4): 368504211044848, 2021 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-34612738

RESUMEN

The key characteristics of the sliding mode control (SMC) are the ability to manage unmodeled dynamics with rapid response and the inherent robustness of parametric differences, making it an appropriate choice for the control of power electronic converters. However, its drawback of changing switching frequency causes critical electro-magnetic compatibility and switching power loss issues. This paper addresses the problem by proposing a dynamic integral sliding mode control for power converters having fixed switching frequency. A special hardware test rig is developed and tested under unregulated 12.5-22.5 V input and 30 V output. The experimental findings indicate excellent controller efficiency under wide range of loads and uncertain input voltage conditions. In addition, the findings indicate that the closed-loop system is robust to sudden differences in load conditions. This technique provides an improvement of 24.52% in the rise time, 20.10% in the settling time and 42.85% in robustness of the controller as compared to conventional controllers. Furthermore, the comparison with the existing fixed-frequency sliding mode control techniques is presented in a tabular form.

2.
Sci Prog ; 104(2): 368504211025409, 2021.
Artículo en Inglés | MEDLINE | ID: mdl-34120527

RESUMEN

In this paper, a novel modified optimization algorithm is presented, which combines Nelder-Mead (NM) method with a gradient-based approach. The well-known Nelder Mead optimization technique is widely used but it suffers from convergence issues in higher dimensional complex problems. Unlike the NM, in this proposed technique we have focused on two issues of the NM approach, one is shape of the simplex which is reshaped at each iteration according to the objective function, so we used a fixed shape of the simplex and we regenerate the simplex at each iteration and the second issue is related to reflection and expansion steps of the NM technique in each iteration, NM used fixed value of α, that is, α = 1 for reflection and α = 2 for expansion and replace the worst point of the simplex with that new point in each iteration. In this way NM search the optimum point. In proposed algorithm the optimum value of the parameter α is computed and then centroid of new simplex is originated at this optimum point and regenerate the simplex with this centroid in each iteration that optimum value of α will ensure the fast convergence of the proposed technique. The proposed algorithm has been applied to the real time implementation of the transversal adaptive filter. The application used to demonstrate the performance of the proposed technique is a well-known convex optimization problem having quadratic cost function, and results show that the proposed technique shows fast convergence than the Nelder-Mead method for lower dimension problems and the proposed technique has also good convergence for higher dimensions, that is, for higher filter taps problem. The proposed technique has also been compared with stochastic techniques like LMS and NLMS (benchmark) techniques. The proposed technique shows good results against LMS. The comparison shows that the modified algorithm guarantees quite acceptable convergence with improved accuracy for higher dimensional identification problems.

3.
IET Syst Biol ; 13(4): 204-211, 2019 08.
Artículo en Inglés | MEDLINE | ID: mdl-31318338

RESUMEN

A significant loss of p53 protein, an anti-tumour agent, is observed in early cancerous cells. Induction of small molecules based drug is by far the most prominent technique to revive and maintain wild-type p53 to the desired level. In this study, a sliding mode control (SMC) based robust non-linear technique is presented for the drug design of a control-oriented p53 model. The control input generated by conventional SMC is discontinuous; however, depending on the physical nature of the system, drug infusion needs to be continuous. Therefore, to obtain a smooth control signal, a dynamic SMC (DSMC) is designed. Moreover, the boundedness of the zero-dynamics is also proved. To make the model-based control design possible, the unknown states of the system are estimated using an equivalent control based, reduced-order sliding mode observer. The robustness of the proposed technique is assessed by introducing input disturbance and parametric uncertainty in the system. The effectiveness of the proposed control scheme is witnessed by performing in-silico trials, revealing that the sustained level of p53 can be achieved by controlled drug administration. Moreover, a comparative quantitative analysis shows that both controllers yield similar performance. However, DSMC consumes less control energy.


Asunto(s)
Modelos Biológicos , Proteína p53 Supresora de Tumor/metabolismo , Algoritmos , Simulación por Computador , Dinámicas no Lineales , Proteínas Proto-Oncogénicas c-mdm2/metabolismo , Incertidumbre
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