RESUMEN
Introduction and importance: Pilomatricoma (PMC) is a benign adnexal dermal or subcutaneous tumor, which is derived from immature hair matrix cells. It makes up around 20% of all tumors related to hair follicles in most series and is therefore the most common hair-follicle neoplasm. Nevertheless, diagnosing it remains intricate due to the prevalence of more frequent pathological conditions in soft-tissue. Anatomopathological examination proves to be a valuable asset, offering a definitive and certain diagnosis. Case presentation: The authors hereby present a case of a 17-year-old patient with no medical history, who was referred to our medical unit subsequent to the emergence of swelling in the right calf. MRI results highlighted the presence of a subcutaneous nodule situated on the right calf. Following a percutaneous biopsy, the diagnosis of PMC was definitively confirmed. A successful surgical excision of the tumor was performed, and the postoperative progress demonstrated positive outcomes. Clinical discussion: PMC usually appears as flesh-colored to white, firm papules or papulonodules that may have an overlying pink to blue hue. MRI plays a crucial role in diagnosis, as it delineates the tumor's extent in relation to the skin and muscle compartments. Preoperative histological confirmation is essential to rule out other potential diagnoses and precisely establish the required resection margins. Conclusion: PMC is an infrequent occurrence in general surgery departments. General surgeons should, however, be well-acquainted with this benign tumor while assessing soft-tissue masses.
RESUMEN
INTRODUCTION: Metastatic lung adenocarcinoma in the thyroid is very rare. The clinical presentation and the radiological findings for metastasis carcinoma are nonspecific and do not allow the distinction between metastatic lung carcinoma and primary thyroid tumor. CASE PRESENTATION: We report the case of a pulmonary papillary adenocarcinoma revealed by a thyroid metastasis in a 62-year-old and non-smoker patient with no history of cancer. DISCUSSION: Thyroid metastasis revealing a primary adenocarcinoma of lung is extremely rare. In the absence of a history of lung cancer, the histological appearance of a papillary adenocarcinoma localized in the thyroid can be misdiagnosed as a primary thyroid cancer given the non-specificity of the clinical, radiological and histological presentations. Immunohistochemical analysis and molecular studies are the gold standards for establishing the diagnosis of the primary site. CONCLUSION: In this report we aim to discuss the histological and immunohistochemical features of lung adenocarcinoma metastazing in thyroid gland through a literature review. We are also targeting to highlight the essential role of immunohistochemistry and molecular study for the confirmation of the primary pulmonary origin and to discuss therapy for patients with lung cancer metastatic in the thyroid [17].