RESUMEN
OBJECTIVE: To evaluate body composition and fasting insulin level in preterm infants receiving preterm formulas (higher protein plus docosahexaenoic acid) for longer periods compared with a recent historical cohort receiving these formulas for shorter periods. STUDY DESIGN: A total of 95 infants fed preterm formula for 6 months or longer (postdischarge formula group) and 87 infants fed preterm formula only during their hospital stay (hospital formula group) were included in this arm of the study. RESULTS: Bone mineral density, content, and lean mass were not different at 1 year and 2 years. However, in the postdischarge formula group, total fat mass (%) was lower by the second year (19.3% ± 5.3% vs 21.7% ± 4.2%; P < .01), trunk fat was lower by the first year (14.7% ± 5.0% vs 16.9% ± 4.9%; P < .005) and at the second year (14.1% ± 5.7% vs 17.2% ± 4.7%; P < .001), and fasting insulin was lower by the first year (13.2% ± 7.1% vs 17.2% ± 13.6% mIU/L; P = .06) and at the second year (13.6% ± 6.1% vs 26.4% ± 14.2%; P < .001). CONCLUSION: Preterm infants fed formulas enriched with docosahexaenoic acid may have a better subsequent metabolic profile.
Asunto(s)
Composición Corporal , Fórmulas Infantiles , Recien Nacido Prematuro/metabolismo , Resistencia a la Insulina , Insulina/metabolismo , Femenino , Humanos , Recién Nacido , Unidades de Cuidado Intensivo Neonatal , Masculino , Alta del Paciente , Estudios Prospectivos , Factores de TiempoAsunto(s)
Humanos , Deficiencia de Vitamina D/complicaciones , Deficiencia de Vitamina D/prevención & control , Osteoporosis/prevención & control , Vitamina D/uso terapéutico , Consenso , Deficiencia de Vitamina D/epidemiología , Deficiencia de Vitamina D/tratamiento farmacológico , Fracturas Óseas/etiología , Fracturas Óseas/prevención & control , América Latina , Osteoporosis/etiología , Vitamina D/metabolismoRESUMEN
BACKGROUND: Calcitriol deficit has been described in patients with acute lymphoblast leukemia (ALL). The aim of this randomized case-control trial is to investigate the effectiveness of calcitriol administration during the first year of treatment to protect bone mass. Sixteen children recently diagnosed with ALL, aged 1.7 to 11.5 years, average 5.5, completed the study. Anthropometrical measurements, food intake record, physical activity, and bone pain were registered. Dual energy x-ray absorptiometry was performed at the completion of remission induction chemotherapy (after 1 mo) to measure bone mineral density (BMD) at hip, lumbar spine and whole body, and total bone mineral content and 1 year after. Half of them were randomly assigned to receive calcitriol during 1 year. STATISTICAL: Kruskal-Wallis, Wilcoxon, Mann-Whitney, and Spearman. RESULTS: Both groups had similar anthropometric measurements and bone densitometric variables increments. Spine BMD significantly increased in calcitriol supplemented children with lower baseline BMD (r=-0.78 and P<0.05). CONCLUSIONS: One-year calcitriol administered to recently diagnosed ALL children did not show impact on bone mass. Greater increment in lumbar spine bone mass was observed in patients who received calcitriol and had lower baseline BMD.
Asunto(s)
Conservadores de la Densidad Ósea/administración & dosificación , Densidad Ósea/efectos de los fármacos , Calcitriol/administración & dosificación , Calcitriol/deficiencia , Leucemia-Linfoma Linfoblástico de Células Precursoras/terapia , Deficiencia de Vitamina D/tratamiento farmacológico , Absorciometría de Fotón , Niño , Preescolar , Ingestión de Alimentos/efectos de los fármacos , Femenino , Estudios de Seguimiento , Cadera/diagnóstico por imagen , Humanos , Lactante , Vértebras Lumbares/diagnóstico por imagen , Masculino , Actividad Motora/efectos de los fármacos , Dolor/tratamiento farmacológico , Dolor/etiología , Leucemia-Linfoma Linfoblástico de Células Precursoras/complicaciones , Leucemia-Linfoma Linfoblástico de Células Precursoras/diagnóstico por imagen , Deficiencia de Vitamina D/complicaciones , Deficiencia de Vitamina D/diagnóstico por imagenRESUMEN
Background: In a previous study we reported that healthy children born at 34 or fewer gestational weeks, with adequate weight for gestational age, had not completed their bone catch-up at mean age of 6.3 years. Aim: This is a follow up report, performed on the same population one year later to determine at which age premature - born children achieve their bone mineral density (BMD) catch-up, compared to term-born controls. Material and methods: Fifteen children mean age 7years 3 months, born at 25 to 34 weeks of gestation, with a birth weight of 740 to 2.200 g were studied Radius, lumbar spine and femoral neck bone mineral density, whole body bone mineral content and body composition were assessed by DEXA. Results: Height, body mass index, peripheral BMD, axial BMD, fat and lean body mass in these children were not different from term born controls. Conclusions: Premature born children with adequate weight for gestational age, achieved peripheral and axial bone mineral density catch-up at the age of 7 to 8 years.
Asunto(s)
Niño , Femenino , Humanos , Recién Nacido , Masculino , Peso al Nacer/fisiología , Densidad Ósea , Recien Nacido Prematuro/fisiología , Antropometría , Índice de Masa Corporal , Estudios de Casos y Controles , Chile , Estudios de Seguimiento , Edad Gestacional , Estadísticas no ParamétricasRESUMEN
BACKGROUND: In a previous study we reported that healthy children born at 34 or fewer gestational weeks, with adequate weight for gestational age, had not completed their bone catch-up at mean age of 6.3 years. AIM: This is a follow up report, performed on the same population one year later to determine at which age premature - born children achieve their bone mineral density (BMD) catch-up, compared to term-born controls. MATERIAL AND METHODS: Fifteen children mean age 7 years 3 months, born at 25 to 34 weeks of gestation, with a birth weight of 740 to 2.200 g were studied Radius, lumbar spine and femoral neck bone mineral density, whole body bone mineral content and body composition were assessed by DEXA. RESULTS: Height, body mass index, peripheral BMD, axial BMD, fat and lean body mass in these children were not different from term born controls. CONCLUSIONS: Premature born children with adequate weight for gestational age, achieved peripheral and axial bone mineral density catch-up at the age of 7 to 8 years.